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Page 1
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.
Hörnig M, Markoutsa S, Häfner AK, George S, Wisniewska JM, Rödl CB, Hofmann B, Maier T, Karas M, Werz O, Steinhilber D. Hörnig M, et al. Among authors: hofmann b. Biochim Biophys Acta. 2012 Feb;1821(2):279-86. doi: 10.1016/j.bbalip.2011.11.001. Epub 2011 Nov 23. Biochim Biophys Acta. 2012. PMID: 22137889
PhAST: pharmacophore alignment search tool.
Hähnke V, Hofmann B, Grgat T, Proschak E, Steinhilber D, Schneider G. Hähnke V, et al. Among authors: hofmann b. J Comput Chem. 2009 Apr 15;30(5):761-71. doi: 10.1002/jcc.21095. J Comput Chem. 2009. PMID: 18727161
Bioactivity-guided mapping and navigation of chemical space.
Renner S, van Otterlo WA, Dominguez Seoane M, Möcklinghoff S, Hofmann B, Wetzel S, Schuffenhauer A, Ertl P, Oprea TI, Steinhilber D, Brunsveld L, Rauh D, Waldmann H. Renner S, et al. Among authors: hofmann b. Nat Chem Biol. 2009 Aug;5(8):585-92. doi: 10.1038/nchembio.188. Epub 2009 Jun 28. Nat Chem Biol. 2009. PMID: 19561619
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
Tausch L, Henkel A, Siemoneit U, Poeckel D, Kather N, Franke L, Hofmann B, Schneider G, Angioni C, Geisslinger G, Skarke C, Holtmeier W, Beckhaus T, Karas M, Jauch J, Werz O. Tausch L, et al. Among authors: hofmann b. J Immunol. 2009 Sep 1;183(5):3433-42. doi: 10.4049/jimmunol.0803574. Epub 2009 Jul 31. J Immunol. 2009. PMID: 19648270 Clinical Trial.
Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors.
Rödl CB, Tanrikulu Y, Wisniewska JM, Proschak E, Schneider G, Steinhilber D, Hofmann B. Rödl CB, et al. Among authors: hofmann b. ChemMedChem. 2011 Jun 6;6(6):1001-5. doi: 10.1002/cmdc.201100059. Epub 2011 Apr 19. ChemMedChem. 2011. PMID: 21506275 No abstract available.
714 results