Sayeski PP - Search Results

1

The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

Kirabo A, Park SO, Majumder A, Gali M, Reinhard MK, Wamsley HL, Zhao ZJ, Cogle CR, Bisht KS, Keserü GM, Sayeski PP. Kirabo A, et al. Among authors: sayeski pp. Neoplasia. 2011 Nov;13(11):1058-68. doi: 10.1593/neo.111112. Neoplasia. 2011. PMID: 22131881 Free PMC article.

2

Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.

Majumder A, Govindasamy L, Magis A, Kiss R, Polgár T, Baskin R, Allan RW, Agbandje-McKenna M, Reuther GW, Keseru GM, Bisht KS, Sayeski PP. Majumder A, et al. Among authors: sayeski pp. J Biol Chem. 2010 Oct 8;285(41):31399-407. doi: 10.1074/jbc.M110.168211. Epub 2010 Jul 28. J Biol Chem. 2010. PMID: 20667821 Free PMC article.

3

The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.

Kirabo A, Embury J, Kiss R, Polgár T, Gali M, Majumder A, Bisht KS, Cogle CR, Keseru GM, Sayeski PP. Kirabo A, et al. Among authors: sayeski pp. J Biol Chem. 2011 Feb 11;286(6):4280-91. doi: 10.1074/jbc.M110.200774. Epub 2010 Dec 2. J Biol Chem. 2011. PMID: 21127060 Free PMC article.

4

Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments.

Majumder A, Kirabo A, Karrupiah K, Tsuda S, Caldwell-Busby J, Cardounel AJ, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: sayeski pp. Biochemistry. 2011 Sep 13;50(36):7774-86. doi: 10.1021/bi200847n. Epub 2011 Aug 17. Biochemistry. 2011. PMID: 21823612 Free PMC article.

5

A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.

Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: sayeski pp. Exp Hematol. 2012 Jan;40(1):22-34. doi: 10.1016/j.exphem.2011.10.003. Epub 2011 Oct 20. Exp Hematol. 2012. PMID: 22019628 Free PMC article.

6

Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation.

Baskin R, Gali M, Park SO, Zhao ZJ, Keseru GM, Bisht KS, Sayeski PP. Baskin R, et al. Among authors: sayeski pp. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1402-7. doi: 10.1016/j.bmcl.2011.12.042. Epub 2011 Dec 21. Bioorg Med Chem Lett. 2012. PMID: 22227213 Free PMC article.

7

The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.

Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keserű GM, Cogle CR, Sayeski PP. Kirabo A, et al. Among authors: sayeski pp. Am J Pathol. 2012 Sep;181(3):858-65. doi: 10.1016/j.ajpath.2012.05.033. Epub 2012 Jul 13. Am J Pathol. 2012. PMID: 22796437 Free PMC article.

8

The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

Baskin R, Park SO, Keserű GM, Bisht KS, Wamsley HL, Sayeski PP. Baskin R, et al. Among authors: sayeski pp. PLoS One. 2014 Aug 27;9(8):e105568. doi: 10.1371/journal.pone.0105568. eCollection 2014. PLoS One. 2014. PMID: 25162558 Free PMC article.

9

The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors.

Baskin R, Majumder A, Sayeski PP. Baskin R, et al. Among authors: sayeski pp. Curr Med Chem. 2010;17(36):4551-8. doi: 10.2174/092986710794182953. Curr Med Chem. 2010. PMID: 21062251 Free PMC article. Review.

10

Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.

McDoom I, Ma X, Kirabo A, Lee KY, Ostrov DA, Sayeski PP. McDoom I, et al. Among authors: sayeski pp. Biochemistry. 2008 Aug 12;47(32):8326-34. doi: 10.1021/bi800867d. Epub 2008 Jul 18. Biochemistry. 2008. PMID: 18636744 Free PMC article.

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