Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways.
Griesser M, Suzuki T, Tejera N, Mont S, Boeglin WE, Pozzi A, Schneider C.
Griesser M, et al. Among authors: schneider c.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6945-50. doi: 10.1073/pnas.1019473108. Epub 2011 Apr 11.
Proc Natl Acad Sci U S A. 2011.
PMID: 21482803
Free PMC article.
The 5-LOX product 5S-hydroxyeicosatetraenoic acid, however, can also serve as an efficient substrate for COX-2, forming a bicyclic diendoperoxide with structural similarities to the arachidonic acid-derived prostaglandin endoperoxide PGH(2) [Schneider C, et al. (200 …
The 5-LOX product 5S-hydroxyeicosatetraenoic acid, however, can also serve as an efficient substrate for COX-2, forming a bicyclic diendoper …