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The BECN1 N-terminal domain is intrinsically disordered.
Lee EF, Perugini MA, Pettikiriarachchi A, Evangelista M, Keizer DW, Yao S, Fairlie WD. Lee EF, et al. Among authors: perugini ma. Autophagy. 2016;12(3):460-71. doi: 10.1080/15548627.2016.1140292. Autophagy. 2016. PMID: 27046249 Free PMC article.
Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Lee EF, Smith NA, Soares da Costa TP, Meftahi N, Yao S, Harris TJ, Tran S, Pettikiriarachchi A, Perugini MA, Keizer DW, Evangelista M, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: perugini ma. Autophagy. 2019 May;15(5):785-795. doi: 10.1080/15548627.2018.1564557. Epub 2019 Jan 9. Autophagy. 2019. PMID: 30626284 Free PMC article.
Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target.
Soares da Costa TP, Desbois S, Dogovski C, Gorman MA, Ketaren NE, Paxman JJ, Siddiqui T, Zammit LM, Abbott BM, Robins-Browne RM, Parker MW, Jameson GB, Hall NE, Panjikar S, Perugini MA. Soares da Costa TP, et al. Among authors: perugini ma. Structure. 2016 Aug 2;24(8):1282-1291. doi: 10.1016/j.str.2016.05.019. Epub 2016 Jul 14. Structure. 2016. PMID: 27427481 Free article.
Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.
Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA. Atkinson SC, et al. Among authors: perugini ma. Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24. Structure. 2018. PMID: 29804823 Free article.
141 results