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In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.
J Biol Chem. 2011 Nov 25;286(47):40734-42. doi: 10.1074/jbc.M111.274068. Epub 2011 Oct 7.
J Biol Chem. 2011.
PMID: 21984832
Free PMC article.
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
Green OM, McKenzie AR, Shapiro AB, Otterbein L, Ni H, Patten A, Stokes S, Albert R, Kawatkar S, Breed J.
Green OM, et al.
Bioorg Med Chem Lett. 2012 Feb 15;22(4):1510-9. doi: 10.1016/j.bmcl.2012.01.016. Epub 2012 Jan 14.
Bioorg Med Chem Lett. 2012.
PMID: 22297115
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An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.
Larsen NA, Nash TJ, Morningstar M, Shapiro AB, Joubran C, Blackett CJ, Patten AD, Boriack-Sjodin PA, Doig P.
Larsen NA, et al. Among authors: patten ad.
Biochem J. 2012 Sep 15;446(3):405-13. doi: 10.1042/BJ20120596.
Biochem J. 2012.
PMID: 22721802
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Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase.
Doig P, Gorseth E, Nash T, Patten A, Gao N, Blackett C.
Doig P, et al.
Biochem Biophys Res Commun. 2013 Jul 19;437(1):162-7. doi: 10.1016/j.bbrc.2013.06.060. Epub 2013 Jun 24.
Biochem Biophys Res Commun. 2013.
PMID: 23806686
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