Datti A - Search Results

1

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease.

Leung E, Datti A, Cossette M, Goodreid J, McCaw SE, Mah M, Nakhamchik A, Ogata K, El Bakkouri M, Cheng YQ, Wodak SJ, Eger BT, Pai EF, Liu J, Gray-Owen S, Batey RA, Houry WA. Leung E, et al. Among authors: datti a. Chem Biol. 2011 Sep 23;18(9):1167-78. doi: 10.1016/j.chembiol.2011.07.023. Chem Biol. 2011. PMID: 21944755

2

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Schimmer AD. Eberhard Y, et al. Among authors: datti a. Blood. 2009 Oct 1;114(14):3064-73. doi: 10.1182/blood-2009-03-209965. Epub 2009 Jul 9. Blood. 2009. PMID: 19589922 Free article.

3

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

Shahinas D, Liang M, Datti A, Pillai DR. Shahinas D, et al. Among authors: datti a. J Med Chem. 2010 May 13;53(9):3552-7. doi: 10.1021/jm901796s. J Med Chem. 2010. PMID: 20349996

4

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.

Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, Schimmer AD. Sharmeen S, et al. Among authors: datti a. Blood. 2010 Nov 4;116(18):3593-603. doi: 10.1182/blood-2010-01-262675. Epub 2010 Jul 19. Blood. 2010. PMID: 20644115 Free article.

5

Sorafenib as an Inhibitor of RUVBL2.

Nano N, Ugwu F, Seraphim TV, Li T, Azer G, Isaac M, Prakesch M, Barbosa LRS, Ramos CHI, Datti A, Houry WA. Nano N, et al. Among authors: datti a. Biomolecules. 2020 Apr 14;10(4):605. doi: 10.3390/biom10040605. Biomolecules. 2020. PMID: 32295120 Free PMC article.

6

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.

Vizeacoumar FJ, van Dyk N, S Vizeacoumar F, Cheung V, Li J, Sydorskyy Y, Case N, Li Z, Datti A, Nislow C, Raught B, Zhang Z, Frey B, Bloom K, Boone C, Andrews BJ. Vizeacoumar FJ, et al. Among authors: datti a. J Cell Biol. 2010 Jan 11;188(1):69-81. doi: 10.1083/jcb.200909013. J Cell Biol. 2010. PMID: 20065090 Free PMC article.

7

Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

Kartner N, Yao Y, Li K, Crasto GJ, Datti A, Manolson MF. Kartner N, et al. Among authors: datti a. J Biol Chem. 2010 Nov 26;285(48):37476-90. doi: 10.1074/jbc.M110.123281. Epub 2010 Sep 13. J Biol Chem. 2010. PMID: 20837476 Free PMC article.

8

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

Mao X, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, MacLean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. Mao X, et al. Among authors: datti a. Blood. 2011 Feb 10;117(6):1986-97. doi: 10.1182/blood-2010-05-284810. Epub 2010 Dec 6. Blood. 2011. PMID: 21135258 Free article.

9

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT. Page BD, et al. Among authors: datti a. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5605-9. doi: 10.1016/j.bmcl.2011.06.056. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21788134 Free PMC article.

10

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.

McDermott SP, Eppert K, Notta F, Isaac M, Datti A, Al-Awar R, Wrana J, Minden MD, Dick JE. McDermott SP, et al. Among authors: datti a. Blood. 2012 Feb 2;119(5):1200-7. doi: 10.1182/blood-2011-01-330019. Epub 2011 Dec 9. Blood. 2012. PMID: 22160482 Free article.

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