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Genome-wide association studies establish that human intelligence is highly heritable and polygenic.
Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, Ke X, Le Hellard S, Christoforou A, Luciano M, McGhee K, Lopez L, Gow AJ, Corley J, Redmond P, Fox HC, Haggarty P, Whalley LJ, McNeill G, Goddard ME, Espeseth T, Lundervold AJ, Reinvang I, Pickles A, Steen VM, Ollier W, Porteous DJ, Horan M, Starr JM, Pendleton N, Visscher PM, Deary IJ. Davies G, et al. Among authors: steen vm. Mol Psychiatry. 2011 Oct;16(10):996-1005. doi: 10.1038/mp.2011.85. Epub 2011 Aug 9. Mol Psychiatry. 2011. PMID: 21826061 Free PMC article.
Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Fernø J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, Nöthen MM, Hebebrand J, Steen VM. Le Hellard S, et al. Among authors: steen vm. Mol Psychiatry. 2009 Mar;14(3):308-17. doi: 10.1038/sj.mp.4002133. Epub 2008 Jan 15. Mol Psychiatry. 2009. PMID: 18195716
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Le Hellard S, Mühleisen TW, Djurovic S, Fernø J, Ouriaghi Z, Mattheisen M, Vasilescu C, Raeder MB, Hansen T, Strohmaier J, Georgi A, Brockschmidt FF, Melle I, Nenadic I, Sauer H, Rietschel M, Nöthen MM, Werge T, Andreassen OA, Cichon S, Steen VM. Le Hellard S, et al. Among authors: steen vm. Mol Psychiatry. 2010 May;15(5):463-72. doi: 10.1038/mp.2008.110. Epub 2008 Oct 21. Mol Psychiatry. 2010. PMID: 18936756
Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
Le Hellard S, Håvik B, Espeseth T, Breilid H, Løvlie R, Luciano M, Gow AJ, Harris SE, Starr JM, Wibrand K, Lundervold AJ, Porteous DJ, Bramham CR, Deary IJ, Reinvang I, Steen VM. Le Hellard S, et al. Among authors: steen vm. PLoS One. 2009 Oct 21;4(10):e7534. doi: 10.1371/journal.pone.0007534. PLoS One. 2009. PMID: 19844571 Free PMC article.
The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.
Håvik B, Le Hellard S, Rietschel M, Lybæk H, Djurovic S, Mattheisen M, Mühleisen TW, Degenhardt F, Priebe L, Maier W, Breuer R, Schulze TG, Agartz I, Melle I, Hansen T, Bramham CR, Nöthen MM, Stevens B, Werge T, Andreassen OA, Cichon S, Steen VM. Håvik B, et al. Among authors: steen vm. Biol Psychiatry. 2011 Jul 1;70(1):35-42. doi: 10.1016/j.biopsych.2011.01.030. Epub 2011 Mar 24. Biol Psychiatry. 2011. PMID: 21439553
Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders.
Ersland KM, Christoforou A, Stansberg C, Espeseth T, Mattheisen M, Mattingsdal M, Hardarson GA, Hansen T, Fernandes CP, Giddaluru S, Breuer R, Strohmaier J, Djurovic S, Nöthen MM, Rietschel M, Lundervold AJ, Werge T, Cichon S, Andreassen OA, Reinvang I, Steen VM, Le Hellard S. Ersland KM, et al. Among authors: steen vm. PLoS One. 2012;7(2):e31687. doi: 10.1371/journal.pone.0031687. Epub 2012 Feb 22. PLoS One. 2012. PMID: 22384057 Free PMC article.
Linkage-disequilibrium-based binning affects the interpretation of GWASs.
Christoforou A, Dondrup M, Mattingsdal M, Mattheisen M, Giddaluru S, Nöthen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Jonassen I, Steen VM, Puntervoll P, Le Hellard S. Christoforou A, et al. Among authors: steen vm. Am J Hum Genet. 2012 Apr 6;90(4):727-33. doi: 10.1016/j.ajhg.2012.02.025. Epub 2012 Mar 22. Am J Hum Genet. 2012. PMID: 22444669 Free PMC article.
216 results