Cochran JR - Search Results

1

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.

Papo N, Silverman AP, Lahti JL, Cochran JR. Papo N, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14067-72. doi: 10.1073/pnas.1016635108. Epub 2011 Aug 8. Proc Natl Acad Sci U S A. 2011. PMID: 21825147 Free PMC article.

2

Developing therapeutic proteins by engineering ligand-receptor interactions.

Jones DS, Silverman AP, Cochran JR. Jones DS, et al. Among authors: cochran jr. Trends Biotechnol. 2008 Sep;26(9):498-505. doi: 10.1016/j.tibtech.2008.05.009. Epub 2008 Jul 31. Trends Biotechnol. 2008. PMID: 18675482 Review.

3

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.

Silverman AP, Levin AM, Lahti JL, Cochran JR. Silverman AP, et al. Among authors: cochran jr. J Mol Biol. 2009 Jan 30;385(4):1064-75. doi: 10.1016/j.jmb.2008.11.004. Epub 2008 Nov 12. J Mol Biol. 2009. PMID: 19038268 Free PMC article.

4

Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

Kimura RH, Levin AM, Cochran FV, Cochran JR. Kimura RH, et al. Among authors: cochran fv, cochran jr. Proteins. 2009 Nov 1;77(2):359-69. doi: 10.1002/prot.22441. Proteins. 2009. PMID: 19452550 Free PMC article.

5

Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein.

Lahti JL, Silverman AP, Cochran JR. Lahti JL, et al. Among authors: cochran jr. PLoS Comput Biol. 2009 Sep;5(9):e1000499. doi: 10.1371/journal.pcbi.1000499. Epub 2009 Sep 4. PLoS Comput Biol. 2009. PMID: 19730675 Free PMC article.

6

Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z. Jiang L, et al. Among authors: cochran jr. J Nucl Med. 2010 Feb;51(2):251-258. doi: 10.2967/jnumed.109.069831. J Nucl Med. 2010. PMID: 20124048 Free PMC article.

7

Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.

Silverman AP, Kariolis MS, Cochran JR. Silverman AP, et al. Among authors: cochran jr. J Mol Recognit. 2011 Jan-Feb;24(1):127-35. doi: 10.1002/jmr.1036. J Mol Recognit. 2011. PMID: 21194123

8

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.

Lahti JL, Lui BH, Beck SE, Lee SS, Ly DP, Longaker MT, Yang GP, Cochran JR. Lahti JL, et al. Among authors: cochran jr. FEBS Lett. 2011 Apr 20;585(8):1135-9. doi: 10.1016/j.febslet.2011.03.044. Epub 2011 Mar 23. FEBS Lett. 2011. PMID: 21439278 Free PMC article.

9

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.

Jones DS 2nd, Tsai PC, Cochran JR. Jones DS 2nd, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13035-40. doi: 10.1073/pnas.1102561108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788476 Free PMC article.

10

Discovery of improved EGF agonists using a novel in vitro screening platform.

Lui BH, Cochran JR, Swartz JR. Lui BH, et al. Among authors: cochran jr. J Mol Biol. 2011 Oct 21;413(2):406-15. doi: 10.1016/j.jmb.2011.08.028. Epub 2011 Aug 23. J Mol Biol. 2011. PMID: 21888916

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