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Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality.
Li Z, Jiang J, Ficarro SB, Beyett TS, To C, Tavares I, Zhu Y, Li J, Eck MJ, Jänne PA, Marto JA, Zhang T, Che J, Gray NS. Li Z, et al. Among authors: eck mj. ACS Cent Sci. 2024 Feb 26;10(6):1156-1166. doi: 10.1021/acscentsci.3c01245. eCollection 2024 Jun 26. ACS Cent Sci. 2024. PMID: 38947214 Free PMC article.
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: eck mj. Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3. Commun Chem. 2024. PMID: 38378740 Free PMC article.
Signaling from RAS to RAF: The Molecules and Their Mechanisms.
Jeon H, Tkacik E, Eck MJ. Jeon H, et al. Among authors: eck mj. Annu Rev Biochem. 2024 Aug;93(1):289-316. doi: 10.1146/annurev-biochem-052521-040754. Epub 2024 Jul 2. Annu Rev Biochem. 2024. PMID: 38316136 Free article. Review.
Cryo-EM structure of a RAS/RAF recruitment complex.
Park E, Rawson S, Schmoker A, Kim BW, Oh S, Song K, Jeon H, Eck MJ. Park E, et al. Among authors: eck mj. Nat Commun. 2023 Jul 29;14(1):4580. doi: 10.1038/s41467-023-40299-6. Nat Commun. 2023. PMID: 37516774 Free PMC article.
Oncogenic K-Ras suppresses global miRNA function.
Shui B, Beyett TS, Chen Z, Li X, La Rocca G, Gazlay WM, Eck MJ, Lau KS, Ventura A, Haigis KM. Shui B, et al. Among authors: eck mj. Mol Cell. 2023 Jul 20;83(14):2509-2523.e13. doi: 10.1016/j.molcel.2023.06.008. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402366 Free PMC article.
152 results