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[Synthetic lethality as a new concept for the treatment of cancer].
Herter-Sprie GS, Chen S, Höpker K, Reinhardt HC. Herter-Sprie GS, et al. Among authors: hopker k. Dtsch Med Wochenschr. 2011 Jul;136(30):1526-30. doi: 10.1055/s-0031-1281549. Epub 2011 Jul 25. Dtsch Med Wochenschr. 2011. PMID: 21789751 Review. German.
Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi MP, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo PD, Pallocca M, Höpker K, Moretti F, Mattei E, Reinhardt HC, Floridi A, Passananti C, Benzing T, Blandino G, Fanciulli M. Desantis A, et al. Among authors: hopker k. Cell Death Dis. 2015 May 21;6(5):e1764. doi: 10.1038/cddis.2015.117. Cell Death Dis. 2015. PMID: 25996291 Free PMC article.
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. Höpker K, et al. EMBO J. 2012 Oct 17;31(20):3961-75. doi: 10.1038/emboj.2012.236. Epub 2012 Aug 21. EMBO J. 2012. PMID: 22909821 Free PMC article.
Putting the brakes on p53-driven apoptosis.
Höpker K, Hagmann H, Khurshid S, Chen S, Schermer B, Benzing T, Reinhardt HC. Höpker K, et al. Cell Cycle. 2012 Nov 15;11(22):4122-8. doi: 10.4161/cc.21997. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983126 Free PMC article.
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K. Welcker D, et al. Among authors: hopker k. Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11. Oncogene. 2018. PMID: 29321668
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma.
Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M. Bruno T, et al. Among authors: hopker k. Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566. Blood Adv. 2020. PMID: 33186461 Free PMC article.
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.
Schermer B, Höpker K, Omran H, Ghenoiu C, Fliegauf M, Fekete A, Horvath J, Köttgen M, Hackl M, Zschiedrich S, Huber TB, Kramer-Zucker A, Zentgraf H, Blaukat A, Walz G, Benzing T. Schermer B, et al. Among authors: hopker k. EMBO J. 2005 Dec 21;24(24):4415-24. doi: 10.1038/sj.emboj.7600885. Epub 2005 Nov 24. EMBO J. 2005. PMID: 16308564 Free PMC article.
27 results