de Kloe GE - Search Results

1

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Verheij MH, et al. Among authors: de kloe ge. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5460-4. doi: 10.1016/j.bmcl.2011.06.123. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782429 Free PMC article.

2

Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.

Wijtmans M, de Graaf C, de Kloe G, Istyastono EP, Smit J, Lim H, Boonnak R, Nijmeijer S, Smits RA, Jongejan A, Zuiderveld O, de Esch IJ, Leurs R. Wijtmans M, et al. J Med Chem. 2011 Mar 24;54(6):1693-703. doi: 10.1021/jm1013488. Epub 2011 Feb 24. J Med Chem. 2011. PMID: 21348462

3

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ. de Kloe GE, et al. J Med Chem. 2010 Oct 14;53(19):7192-201. doi: 10.1021/jm100834y. J Med Chem. 2010. PMID: 20828128

4

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.

de Graaf C, Vischer HF, de Kloe GE, Kooistra AJ, Nijmeijer S, Kuijer M, Verheij MH, England PJ, van Muijlwijk-Koezen JE, Leurs R, de Esch IJ. de Graaf C, et al. Among authors: de kloe ge. Drug Discov Today. 2013 Apr;18(7-8):323-30. doi: 10.1016/j.drudis.2012.12.003. Epub 2012 Dec 22. Drug Discov Today. 2013. PMID: 23266367

5

Transforming fragments into candidates: small becomes big in medicinal chemistry.

de Kloe GE, Bailey D, Leurs R, de Esch IJ. de Kloe GE, et al. Drug Discov Today. 2009 Jul;14(13-14):630-46. doi: 10.1016/j.drudis.2009.03.009. Epub 2009 Mar 31. Drug Discov Today. 2009. PMID: 19443265 Review.

6

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H. Kool J, et al. Among authors: de kloe ge. J Med Chem. 2010 Jun 24;53(12):4720-30. doi: 10.1021/jm100230k. J Med Chem. 2010. PMID: 20518527

7

High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology.

Kool J, Heus F, de Kloe G, Lingeman H, Smit AB, Leurs R, Edink E, De Esch IJ, Irth H, Niessen WM. Kool J, et al. J Biomol Screen. 2011 Sep;16(8):917-24. doi: 10.1177/1087057111413921. Epub 2011 Jul 28. J Biomol Screen. 2011. PMID: 21799121

8

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

Kool J, de Kloe G, Denker AD, van Altena K, Smoluch M, van Iperen D, Nahar TT, Limburg RJ, Niessen WM, Lingeman H, Leurs R, de Esch IJ, Smit AB, Irth H. Kool J, et al. Anal Chem. 2011 Jan 1;83(1):125-32. doi: 10.1021/ac102001g. Epub 2010 Nov 30. Anal Chem. 2011. PMID: 21117623

9

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays.

Heus F, Giera M, de Kloe GE, van Iperen D, Buijs J, Nahar TT, Smit AB, Lingeman H, de Esch IJ, Niessen WM, Irth H, Kool J. Heus F, et al. Among authors: de kloe ge. Anal Bioanal Chem. 2010 Dec;398(7-8):3023-32. doi: 10.1007/s00216-010-4210-x. Epub 2010 Sep 25. Anal Bioanal Chem. 2010. PMID: 20872136 Free PMC article.

10

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

Stornaiuolo M, De Kloe GE, Rucktooa P, Fish A, van Elk R, Edink ES, Bertrand D, Smit AB, de Esch IJ, Sixma TK. Stornaiuolo M, et al. Among authors: de kloe ge. Nat Commun. 2013;4:1875. doi: 10.1038/ncomms2900. Nat Commun. 2013. PMID: 23695669 Free PMC article.

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