Leurs R - Search Results

1

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Verheij MH, et al. Among authors: leurs r. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5460-4. doi: 10.1016/j.bmcl.2011.06.123. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782429 Free PMC article.

2

New analogs of burimamide as potent and selective histamine H3 receptor antagonists: the effect of chain length variation of the alkyl spacer and modifications of the N-thiourea substituent.

Vollinga RC, Menge WM, Leurs R, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1995 Jun 9;38(12):2244-50. doi: 10.1021/jm00012a025. J Med Chem. 1995. PMID: 7783156

3

Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.

Vollinga RC, Menge WM, Leurs R, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1995 Jan 20;38(2):266-71. doi: 10.1021/jm00002a008. J Med Chem. 1995. PMID: 7830269

4

A new potent and selective histamine H3 receptor agonist, 4-(1H-imidazol-4-ylmethyl)piperidine.

Vollinga RC, de Koning JP, Jansen FP, Leurs R, Menge WM, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1994 Feb 4;37(3):332-3. doi: 10.1021/jm00029a002. J Med Chem. 1994. PMID: 8308858 No abstract available.

5

Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed.

Leurs R, Tulp MT, Menge WM, Adolfs MJ, Zuiderveld OP, Timmerman H. Leurs R, et al. Br J Pharmacol. 1995 Oct;116(4):2315-21. doi: 10.1111/j.1476-5381.1995.tb15071.x. Br J Pharmacol. 1995. PMID: 8564266 Free PMC article.

6

Pharmacological characterisation of the histamine H3 receptor in the rat hippocampus.

Alves-Rodrigues A, Timmerman H, Willems E, Lemstra S, Zuiderveld OP, Leurs R. Alves-Rodrigues A, et al. Among authors: leurs r. Brain Res. 1998 Mar 30;788(1-2):179-86. doi: 10.1016/s0006-8993(97)01537-0. Brain Res. 1998. PMID: 9555002

7

Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.

De Esch IJ, Vollinga RC, Goubitz K, Schenk H, Appelberg U, Hacksell U, Lemstra S, Zuiderveld OP, Hoffmann M, Leurs R, Menge WM, Timmerman H. De Esch IJ, et al. Among authors: leurs r. J Med Chem. 1999 Apr 8;42(7):1115-22. doi: 10.1021/jm9810912. J Med Chem. 1999. PMID: 10197956 Free article.

8

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor.

Wieland K, Laak AM, Smit MJ, Kühne R, Timmerman H, Leurs R. Wieland K, et al. Among authors: leurs r. J Biol Chem. 1999 Oct 15;274(42):29994-30000. doi: 10.1074/jbc.274.42.29994. J Biol Chem. 1999. PMID: 10514483 Free article.

9

Evaluation of [18F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H3 receptor.

Windhorst AD, Timmerman H, Klok RP, Menge WM, Leurs R, Herscheid JD. Windhorst AD, et al. Among authors: leurs r. Bioorg Med Chem. 1999 Sep;7(9):1761-7. doi: 10.1016/s0968-0896(99)00108-x. Bioorg Med Chem. 1999. PMID: 10530922

10

Characterization of the binding site of the histamine H(3) receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide.

Windhorst AD, Timmerman H, Worthington EA, Bijloo GJ, Nederkoorn PH, Menge WM, Leurs R, Herscheid JD. Windhorst AD, et al. Among authors: leurs r. J Med Chem. 2000 May 4;43(9):1754-61. doi: 10.1021/jm981106w. J Med Chem. 2000. PMID: 10794692

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