Downing JR - Search Results

1

Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.

Shurtleff SA, Downing JR, Rock CO, Hawkins SA, Roussel MF, Sherr CJ. Shurtleff SA, et al. Among authors: downing jr. EMBO J. 1990 Aug;9(8):2415-21. doi: 10.1002/j.1460-2075.1990.tb07417.x. EMBO J. 1990. PMID: 2164469 Free PMC article.

2

Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation.

Ohtsuka M, Roussel MF, Sherr CJ, Downing JR. Ohtsuka M, et al. Among authors: downing jr. Mol Cell Biol. 1990 Apr;10(4):1664-71. doi: 10.1128/mcb.10.4.1664-1671.1990. Mol Cell Biol. 1990. PMID: 2157138 Free PMC article.

3

Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.

Roussel MF, Downing JR, Sherr CJ. Roussel MF, et al. Among authors: downing jr. Oncogene. 1990 Jan;5(1):25-30. Oncogene. 1990. PMID: 2157180

4

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Roussel MF, Shurtleff SA, Downing JR, Sherr CJ. Roussel MF, et al. Among authors: downing jr. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6738-42. doi: 10.1073/pnas.87.17.6738. Proc Natl Acad Sci U S A. 1990. PMID: 2168557 Free PMC article.

5

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

Downing JR, Roussel MF, Sherr CJ. Downing JR, et al. Mol Cell Biol. 1989 Jul;9(7):2890-6. doi: 10.1128/mcb.9.7.2890-2896.1989. Mol Cell Biol. 1989. PMID: 2528680 Free PMC article.

6

Inhibition of colony-stimulating factor-1 activity by monoclonal antibodies to the human CSF-1 receptor.

Sherr CJ, Ashmun RA, Downing JR, Ohtsuka M, Quan SG, Golde DW, Roussel MF. Sherr CJ, et al. Among authors: downing jr. Blood. 1989 May 15;73(7):1786-93. Blood. 1989. PMID: 2540857 Free article.

7

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

Downing JR, Margolis BL, Zilberstein A, Ashmun RA, Ullrich A, Sherr CJ, Schlessinger J. Downing JR, et al. EMBO J. 1989 Nov;8(11):3345-50. doi: 10.1002/j.1460-2075.1989.tb08496.x. EMBO J. 1989. PMID: 2555162 Free PMC article.

8

Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line.

Downing JR, Rettenmier CW, Sherr CJ. Downing JR, et al. Mol Cell Biol. 1988 Apr;8(4):1795-9. doi: 10.1128/mcb.8.4.1795-1799.1988. Mol Cell Biol. 1988. PMID: 2837654 Free PMC article.

9

Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain.

Roussel MF, Downing JR, Ashmun RA, Rettenmier CW, Sherr CJ. Roussel MF, et al. Among authors: downing jr. Proc Natl Acad Sci U S A. 1988 Aug;85(16):5903-7. doi: 10.1073/pnas.85.16.5903. Proc Natl Acad Sci U S A. 1988. PMID: 2842754 Free PMC article.

10

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential.

Roussel MF, Downing JR, Rettenmier CW, Sherr CJ. Roussel MF, et al. Among authors: downing jr. Cell. 1988 Dec 23;55(6):979-88. doi: 10.1016/0092-8674(88)90243-7. Cell. 1988. PMID: 2974321

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