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Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
J Med Chem. 2011 Jul 14;54(13):4427-45. doi: 10.1021/jm200018k. Epub 2011 Jun 2.
J Med Chem. 2011.
PMID: 21634377
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.
DiMauro EF, Buchanan JL, Cheng A, Emkey R, Hitchcock SA, Huang L, Huang MY, Janosky B, Lee JH, Li X, Martin MW, Tomlinson SA, White RD, Zheng XM, Patel VF, Fremeau RT Jr.
DiMauro EF, et al. Among authors: janosky b.
Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. doi: 10.1016/j.bmcl.2008.06.096. Epub 2008 Jul 3.
Bioorg Med Chem Lett. 2008.
PMID: 18640038
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Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.
Albrecht BK, Berry V, Boezio AA, Cao L, Clarkin K, Guo W, Harmange JC, Hierl M, Huang L, Janosky B, Knop J, Malmberg A, McDermott JS, Nguyen HQ, Springer SK, Waldon D, Woodin K, McDonough SI.
Albrecht BK, et al. Among authors: janosky b.
Bioorg Med Chem Lett. 2008 Oct 1;18(19):5209-12. doi: 10.1016/j.bmcl.2008.08.080. Epub 2008 Aug 28.
Bioorg Med Chem Lett. 2008.
PMID: 18789861
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In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases.
Huang L, Be X, Berry L, Moore E, Janosky B, Wells M, Pan WJ, Zhao Z, Lin MH.
Huang L, et al. Among authors: janosky b.
Xenobiotica. 2011 May;41(5):400-8. doi: 10.3109/00498254.2010.548534. Epub 2011 Feb 4.
Xenobiotica. 2011.
PMID: 21294625
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Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance.
Huang L, Berry L, Ganga S, Janosky B, Chen A, Roberts J, Colletti AE, Lin MH.
Huang L, et al. Among authors: janosky b.
Drug Metab Dispos. 2010 Feb;38(2):223-31. doi: 10.1124/dmd.109.029066. Epub 2009 Oct 29.
Drug Metab Dispos. 2010.
PMID: 19875499
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Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Huang L, Chen A, Roberts J, Janosky B, Be X, Berry L, Lin MH.
Huang L, et al. Among authors: janosky b.
Xenobiotica. 2012 Sep;42(9):830-40. doi: 10.3109/00498254.2012.667847. Epub 2012 Mar 22.
Xenobiotica. 2012.
PMID: 22439758
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Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.
Huang L, Li X, Roberts J, Janosky B, Lin MH.
Huang L, et al. Among authors: janosky b.
Xenobiotica. 2015;45(6):547-55. doi: 10.3109/00498254.2014.997324. Epub 2014 Dec 24.
Xenobiotica. 2015.
PMID: 25539457
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