Fischer R - Search Results

1

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues.

Falck JR, Wallukat G, Puli N, Goli M, Arnold C, Konkel A, Rothe M, Fischer R, Müller DN, Schunck WH. Falck JR, et al. Among authors: fischer r. J Med Chem. 2011 Jun 23;54(12):4109-18. doi: 10.1021/jm200132q. Epub 2011 Jun 1. J Med Chem. 2011. PMID: 21591683 Free PMC article.

2

Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension.

Fischer R, Dechend R, Qadri F, Markovic M, Feldt S, Herse F, Park JK, Gapelyuk A, Schwarz I, Zacharzowsky UB, Plehm R, Safak E, Heuser A, Schirdewan A, Luft FC, Schunck WH, Muller DN. Fischer R, et al. Hypertension. 2008 Feb;51(2):540-6. doi: 10.1161/HYPERTENSIONAHA.107.103143. Epub 2007 Dec 24. Hypertension. 2008. PMID: 18158339

3

Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats.

Wenzel K, Wallukat G, Qadri F, Hubner N, Schulz H, Hummel O, Herse F, Heuser A, Fischer R, Heidecke H, Luft FC, Muller DN, Dietz R, Dechend R. Wenzel K, et al. Among authors: fischer r. PLoS One. 2010 Feb 24;5(2):e9409. doi: 10.1371/journal.pone.0009409. PLoS One. 2010. PMID: 20195525 Free PMC article.

4

Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.

Arnold C, Konkel A, Fischer R, Schunck WH. Arnold C, et al. Among authors: fischer r. Pharmacol Rep. 2010 May-Jun;62(3):536-47. doi: 10.1016/s1734-1140(10)70311-x. Pharmacol Rep. 2010. PMID: 20631419 Free article. Review.

5

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.

Arnold C, Markovic M, Blossey K, Wallukat G, Fischer R, Dechend R, Konkel A, von Schacky C, Luft FC, Muller DN, Rothe M, Schunck WH. Arnold C, et al. Among authors: fischer r. J Biol Chem. 2010 Oct 22;285(43):32720-32733. doi: 10.1074/jbc.M110.118406. Epub 2010 Aug 23. J Biol Chem. 2010. PMID: 20732876 Free PMC article.

6

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

Westphal C, Spallek B, Konkel A, Marko L, Qadri F, DeGraff LM, Schubert C, Bradbury JA, Regitz-Zagrosek V, Falck JR, Zeldin DC, Müller DN, Schunck WH, Fischer R. Westphal C, et al. Among authors: fischer r. PLoS One. 2013 Aug 30;8(8):e73490. doi: 10.1371/journal.pone.0073490. eCollection 2013. PLoS One. 2013. PMID: 24023684 Free PMC article.

7

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway.

Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH. Fischer R, et al. J Lipid Res. 2014 Jun;55(6):1150-64. doi: 10.1194/jlr.M047357. Epub 2014 Mar 16. J Lipid Res. 2014. PMID: 24634501 Free PMC article. Clinical Trial.

8

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.

Schunck WH, Konkel A, Fischer R, Weylandt KH. Schunck WH, et al. Among authors: fischer r. Pharmacol Ther. 2018 Mar;183:177-204. doi: 10.1016/j.pharmthera.2017.10.016. Epub 2017 Nov 7. Pharmacol Ther. 2018. PMID: 29080699 Review.

9

Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents.

Adebesin AM, Wesser T, Vijaykumar J, Konkel A, Paudyal MP, Lossie J, Zhu C, Westphal C, Puli N, Fischer R, Schunck WH, Falck JR. Adebesin AM, et al. Among authors: fischer r. J Med Chem. 2019 Nov 27;62(22):10124-10143. doi: 10.1021/acs.jmedchem.9b00952. Epub 2019 Nov 19. J Med Chem. 2019. PMID: 31693857

10

Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation: Rationale and design of the PROMISE-AF phase II study.

Berlin S, Goette A, Summo L, Lossie J, Gebauer A, Al-Saady N, Calo L, Naccarelli G, Schunck WH, Fischer R, Camm AJ, Dobrev D. Berlin S, et al. Among authors: fischer r. Int J Cardiol Heart Vasc. 2020 Jul 10;29:100573. doi: 10.1016/j.ijcha.2020.100573. eCollection 2020 Aug. Int J Cardiol Heart Vasc. 2020. PMID: 32685659 Free PMC article.

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