Coughlan KA - Search Results

1

Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy.

Coughlan KA, Eybye M, Henderson N, DeAntonis CM, Frassetto A, Hanahoe E, Ketova T, Jacquinet E, Presnyak V, Jain R, Marshall J, Martini PGV. Coughlan KA, et al. Mol Genet Metab. 2024 Sep-Oct;143(1-2):108560. doi: 10.1016/j.ymgme.2024.108560. Epub 2024 Aug 5. Mol Genet Metab. 2024. PMID: 39121792

2

Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model.

Zhao XJ, Mohsen AW, Mihalik S, Solo K, Basu S, Aliu E, Shi H, Kochersberger C, Karunanidhi A, Van't Land C, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, DeAntonis C, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: coughlan ka. Hum Mol Genet. 2023 Jul 4;32(14):2347-2356. doi: 10.1093/hmg/ddad076. Hum Mol Genet. 2023. PMID: 37162351 Free PMC article.

3

Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model.

Zhao XJ, Mohsen AW, Mihalik S, Solo K, Aliu E, Shi H, Basu S, Kochersperger C, Van't Land C, Karunanidhi A, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: coughlan ka. Mol Genet Metab. 2023 Jan;138(1):106982. doi: 10.1016/j.ymgme.2022.106982. Epub 2022 Dec 23. Mol Genet Metab. 2023. PMID: 36580829 Free PMC article.

4

Loss of AMPKalpha1 Triggers Centrosome Amplification via PLK4 Upregulation in Mouse Embryonic Fibroblasts.

Zhao Q, Coughlan KA, Zou MH, Song P. Zhao Q, et al. Among authors: coughlan ka. Int J Mol Sci. 2020 Apr 16;21(8):2772. doi: 10.3390/ijms21082772. Int J Mol Sci. 2020. PMID: 32316320 Free PMC article.

5

Correction: Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.

Okon IS, Coughlan KA, Zou MH. Okon IS, et al. Among authors: coughlan ka. J Biol Chem. 2019 Aug 16;294(33):12555. doi: 10.1074/jbc.AAC119.010208. J Biol Chem. 2019. PMID: 31420522 Free PMC article. No abstract available.

6

The effects of troglitazone on AMPK in HepG2 cells.

Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. Allen KM, et al. Among authors: coughlan ka. Arch Biochem Biophys. 2017 Jun 1;623-624:49-57. doi: 10.1016/j.abb.2017.05.010. Epub 2017 May 16. Arch Biochem Biophys. 2017. PMID: 28526426

7

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. Coughlan KA, et al. J Biol Chem. 2016 Mar 11;291(11):5664-5675. doi: 10.1074/jbc.M115.696849. Epub 2016 Jan 21. J Biol Chem. 2016. PMID: 26797128 Free PMC article.

8

Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers.

Okon IS, Ding Y, Coughlan KA, Wang Q, Song P, Benbrook DM, Zou MH. Okon IS, et al. Among authors: coughlan ka. Oncotarget. 2016 Feb 16;7(7):7970-8. doi: 10.18632/oncotarget.6699. Oncotarget. 2016. PMID: 26701889 Free PMC article.

9

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.

Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Coughlan KA, et al. PLoS One. 2015 May 21;10(5):e0127388. doi: 10.1371/journal.pone.0127388. eCollection 2015. PLoS One. 2015. PMID: 25996822 Free PMC article.

10

Gefitinib-mediated reactive oxygen specie (ROS) instigates mitochondrial dysfunction and drug resistance in lung cancer cells.

Okon IS, Coughlan KA, Zhang M, Wang Q, Zou MH. Okon IS, et al. Among authors: coughlan ka. J Biol Chem. 2015 Apr 3;290(14):9101-10. doi: 10.1074/jbc.M114.631580. Epub 2015 Feb 13. J Biol Chem. 2015. PMID: 25681445 Free PMC article.

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