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Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG. Ehlting C, et al. Among authors: radzioch d. J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17. J Biol Chem. 2011. PMID: 21586572 Free PMC article.
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Hitti E, et al. Among authors: radzioch d. Mol Cell Biol. 2006 Mar;26(6):2399-407. doi: 10.1128/MCB.26.6.2399-2407.2006. Mol Cell Biol. 2006. PMID: 16508014 Free PMC article.
MAPKAPK-2 signaling is critical for cutaneous wound healing.
Thuraisingam T, Xu YZ, Eadie K, Heravi M, Guiot MC, Greemberg R, Gaestel M, Radzioch D. Thuraisingam T, et al. Among authors: radzioch d. J Invest Dermatol. 2010 Jan;130(1):278-86. doi: 10.1038/jid.2009.209. J Invest Dermatol. 2010. PMID: 19609314 Free article.
TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.
Moisan J, Camateros P, Thuraisingam T, Marion D, Koohsari H, Martin P, Boghdady ML, Ding A, Gaestel M, Guiot MC, Martin JG, Radzioch D. Moisan J, et al. Among authors: radzioch d. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L987-95. doi: 10.1152/ajplung.00440.2005. Epub 2005 Dec 16. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16361354 Free article.
169 results