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Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Kumar S, et al. Among authors: thal dr. EMBO J. 2011 Jun 1;30(11):2255-65. doi: 10.1038/emboj.2011.138. Epub 2011 Apr 28. EMBO J. 2011. PMID: 21527912 Free PMC article.
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Thal DR, et al. Acta Neuropathol. 2005 Nov;110(5):459-71. doi: 10.1007/s00401-005-1053-1. Epub 2005 Sep 30. Acta Neuropathol. 2005. PMID: 16195918
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Sastre M, et al. Among authors: thal dr. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):443-8. doi: 10.1073/pnas.0503839103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407166 Free PMC article.
249 results