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G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ. Ciccarelli M, et al. Among authors: chuprun jk. Circulation. 2011 May 10;123(18):1953-62. doi: 10.1161/CIRCULATIONAHA.110.988642. Epub 2011 Apr 25. Circulation. 2011. PMID: 21518983 Free PMC article.
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP. Zhu W, et al. Among authors: chuprun jk. Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15. Circ Res. 2012. PMID: 22179058 Free PMC article.
Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.
Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Chen M, et al. Among authors: chuprun jk. Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6. Circ Res. 2013. PMID: 23467820 Free PMC article.
GRK2 in the heart: a GPCR kinase and beyond.
Huang ZM, Gao E, Chuprun JK, Koch WJ. Huang ZM, et al. Among authors: chuprun jk. Antioxid Redox Signal. 2014 Nov 10;21(14):2032-43. doi: 10.1089/ars.2014.5876. Epub 2014 May 13. Antioxid Redox Signal. 2014. PMID: 24702056 Free PMC article. Review.
39 results