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Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.
Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR. Sleiman SF, et al. Among authors: coppola g. J Neurosci. 2011 May 4;31(18):6858-70. doi: 10.1523/JNEUROSCI.0710-11.2011. J Neurosci. 2011. PMID: 21543616 Free PMC article.
The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling.
Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. Ma CH, et al. Among authors: coppola g. J Neurosci. 2011 Dec 14;31(50):18391-400. doi: 10.1523/JNEUROSCI.4550-11.2011. J Neurosci. 2011. PMID: 22171041 Free PMC article.
Genomic medicine enters the neurology clinic.
Coppola G, Geschwind DH. Coppola G, et al. Neurology. 2012 Jul 10;79(2):112-4. doi: 10.1212/WNL.0b013e31825f06d9. Epub 2012 Jun 6. Neurology. 2012. PMID: 22675078 No abstract available.
1,248 results