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Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.
Pallagi P, Venglovecz V, Rakonczay Z Jr, Borka K, Korompay A, Ozsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P. Pallagi P, et al. Among authors: geisz a. Gastroenterology. 2011 Dec;141(6):2228-2239.e6. doi: 10.1053/j.gastro.2011.08.039. Epub 2011 Sep 3. Gastroenterology. 2011. PMID: 21893120 Free PMC article.
Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. Derikx MH, et al. Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127
Functional significance of SPINK1 promoter variants in chronic pancreatitis.
Derikx MH, Geisz A, Kereszturi É, Sahin-Tóth M. Derikx MH, et al. Among authors: geisz a. Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G779-84. doi: 10.1152/ajpgi.00022.2015. Epub 2015 Mar 19. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 25792561 Free PMC article.
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H. Nakano E, et al. Among authors: geisz a. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G688-94. doi: 10.1152/ajpgi.00241.2015. Epub 2015 Aug 27. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26316592 Free PMC article.
SPINK1 Promoter Variants in Chronic Pancreatitis.
Hegyi E, Geisz A, Sahin-Tóth M, Derikx MH, Németh BC, Balázs A, Hritz I, Izbéki F, Halász A, Párniczky A, Takács T, Kelemen D, Sarlós P, Hegyi P, Czakó L; Hungarian Pancreatic Study Group. Hegyi E, et al. Among authors: geisz a. Pancreas. 2016 Jan;45(1):148-53. doi: 10.1097/MPA.0000000000000412. Pancreas. 2016. PMID: 26348468
26 results