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Frat2 mediates the oncogenic activation of Rac by MLL fusions.
Walf-Vorderwülbecke V, de Boer J, Horton SJ, van Amerongen R, Proost N, Berns A, Williams O. Walf-Vorderwülbecke V, et al. Among authors: williams o. Blood. 2012 Dec 6;120(24):4819-28. doi: 10.1182/blood-2012-05-432534. Epub 2012 Oct 16. Blood. 2012. PMID: 23074275 Free article.
In focus: MLL-rearranged leukemia.
de Boer J, Walf-Vorderwülbecke V, Williams O. de Boer J, et al. Among authors: williams o. Leukemia. 2013 Jun;27(6):1224-8. doi: 10.1038/leu.2013.78. Epub 2013 Mar 21. Leukemia. 2013. PMID: 23515098 Review.
Targeting acute myeloid leukemia by drug-induced c-MYB degradation.
Walf-Vorderwülbecke V, Pearce K, Brooks T, Hubank M, van den Heuvel-Eibrink MM, Zwaan CM, Adams S, Edwards D, Bartram J, Samarasinghe S, Ancliff P, Khwaja A, Goulden N, Williams G, de Boer J, Williams O. Walf-Vorderwülbecke V, et al. Among authors: williams o, williams g. Leukemia. 2018 Apr;32(4):882-889. doi: 10.1038/leu.2017.317. Epub 2017 Nov 1. Leukemia. 2018. PMID: 29089643
Identification of a c-MYB-directed therapeutic for acute myeloid leukemia.
Clesham K, Walf-Vorderwülbecke V, Gasparoli L, Virely C, Cantilena S, Tsakaneli A, Inglott S, Adams S, Samarasinghe S, Bartram J, Williams G, de Boer J, Williams O. Clesham K, et al. Among authors: williams o, williams g. Leukemia. 2022 Jun;36(6):1541-1549. doi: 10.1038/s41375-022-01554-9. Epub 2022 Apr 2. Leukemia. 2022. PMID: 35368048 Free PMC article.
ERG is a megakaryocytic oncogene.
Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ. Salek-Ardakani S, et al. Among authors: williams o. Cancer Res. 2009 Jun 1;69(11):4665-73. doi: 10.1158/0008-5472.CAN-09-0075. Cancer Res. 2009. PMID: 19487285
927 results