Webb HK - Search Results

1

Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects.

Chen D, Whitcomb R, MacIntyre E, Tran V, Do ZN, Sabry J, Patel DV, Anandan SK, Gless R, Webb HK. Chen D, et al. Among authors: webb hk. J Clin Pharmacol. 2012 Mar;52(3):319-28. doi: 10.1177/0091270010397049. Epub 2011 Mar 21. J Clin Pharmacol. 2012. PMID: 21422238 Clinical Trial.

2

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.

Anandan SK, Webb HK, Chen D, Wang YX, Aavula BR, Cases S, Cheng Y, Do ZN, Mehra U, Tran V, Vincelette J, Waszczuk J, White K, Wong KR, Zhang LN, Jones PD, Hammock BD, Patel DV, Whitcomb R, MacIntyre DE, Sabry J, Gless R. Anandan SK, et al. Among authors: webb hk. Bioorg Med Chem Lett. 2011 Feb 1;21(3):983-8. doi: 10.1016/j.bmcl.2010.12.042. Epub 2010 Dec 13. Bioorg Med Chem Lett. 2011. PMID: 21211973 Free PMC article.

3

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension.

Zhang LN, Vincelette J, Chen D, Gless RD, Anandan SK, Rubanyi GM, Webb HK, MacIntyre DE, Wang YX. Zhang LN, et al. Among authors: webb hk. Eur J Pharmacol. 2011 Mar 1;654(1):68-74. doi: 10.1016/j.ejphar.2010.12.016. Epub 2010 Dec 25. Eur J Pharmacol. 2011. PMID: 21187082

4

Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors.

Anandan SK, Do ZN, Webb HK, Patel DV, Gless RD. Anandan SK, et al. Among authors: webb hk. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1066-70. doi: 10.1016/j.bmcl.2009.01.013. Epub 2009 Jan 10. Bioorg Med Chem Lett. 2009. PMID: 19168352

5

Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase.

Anandan SK, Webb HK, Do ZN, Gless RD. Anandan SK, et al. Among authors: webb hk. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4259-63. doi: 10.1016/j.bmcl.2009.05.102. Epub 2009 May 30. Bioorg Med Chem Lett. 2009. PMID: 19520575

6

Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia.

Zhang LN, Vincelette J, Cheng Y, Mehra U, Chen D, Anandan SK, Gless R, Webb HK, Wang YX. Zhang LN, et al. Among authors: webb hk. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1265-70. doi: 10.1161/ATVBAHA.109.186064. Epub 2009 Aug 10. Arterioscler Thromb Vasc Biol. 2009. PMID: 19667112

7

Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling.

Liu Y, Webb HK, Fukushima H, Micheli J, Markova S, Olson JL, Kroetz DL. Liu Y, et al. Among authors: webb hk. J Pharmacol Exp Ther. 2012 Jun;341(3):725-34. doi: 10.1124/jpet.111.191247. Epub 2012 Mar 13. J Pharmacol Exp Ther. 2012. PMID: 22414856 Free PMC article.

8

Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase.

Koppelman B, Webb HK, Medicherla S, Almirez R, Feng Y, Chavez JC, Mao CP, Nguyen A, Liu YW, Kapoun AM, Muiru G, Huang YA, Dugar S, Mavunkel BJ, Lim DW, Chakravarty S, Luedtke G, Protter AA, Higgins LS. Koppelman B, et al. Among authors: webb hk. Pharmacology. 2008;81(3):204-20. doi: 10.1159/000112865. Epub 2008 Jan 7. Pharmacology. 2008. PMID: 18176091

9

Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway.

Liu Y, Lu X, Nguyen S, Olson JL, Webb HK, Kroetz DL. Liu Y, et al. Among authors: webb hk. Mol Pharmacol. 2013 Dec;84(6):925-34. doi: 10.1124/mol.113.088302. Epub 2013 Oct 3. Mol Pharmacol. 2013. PMID: 24092818 Free PMC article.

10

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

Sperandio D, Aktoudianakis V, Babaoglu K, Chen X, Elbel K, Chin G, Corkey B, Du J, Jiang B, Kobayashi T, Mackman R, Martinez R, Yang H, Zablocki J, Kusam S, Jordan K, Webb H, Bates JG, Lad L, Mish M, Niedziela-Majka A, Metobo S, Sapre A, Hung M, Jin D, Fung W, Kan E, Eisenberg G, Larson N, Newby ZER, Lansdon E, Tay C, Neve RM, Shevick SL, Breckenridge DG. Sperandio D, et al. Bioorg Med Chem. 2019 Feb 1;27(3):457-469. doi: 10.1016/j.bmc.2018.11.020. Epub 2018 Nov 15. Bioorg Med Chem. 2019. PMID: 30606676

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