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Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.
Montes R, Ayllón V, Gutierrez-Aranda I, Prat I, Hernández-Lamas MC, Ponce L, Bresolin S, Te Kronnie G, Greaves M, Bueno C, Menendez P. Montes R, et al. Among authors: gutierrez aranda i. Blood. 2011 May 5;117(18):4746-58. doi: 10.1182/blood-2010-12-322230. Epub 2011 Mar 9. Blood. 2011. PMID: 21389315 Free article.
A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification.
Bueno C, Montes R, Melen GJ, Ramos-Mejia V, Real PJ, Ayllón V, Sanchez L, Ligero G, Gutierrez-Aranda I, Fernández AF, Fraga MF, Moreno-Gimeno I, Burks D, Plaza-Calonge Mdel C, Rodríguez-Manzaneque JC, Menendez P. Bueno C, et al. Among authors: gutierrez aranda i. Cell Res. 2012 Jun;22(6):986-1002. doi: 10.1038/cr.2012.4. Epub 2012 Jan 3. Cell Res. 2012. PMID: 22212479 Free PMC article.
SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells.
Real PJ, Ligero G, Ayllon V, Ramos-Mejia V, Bueno C, Gutierrez-Aranda I, Navarro-Montero O, Lako M, Menendez P. Real PJ, et al. Among authors: gutierrez aranda i. Mol Ther. 2012 Jul;20(7):1443-53. doi: 10.1038/mt.2012.49. Epub 2012 Apr 10. Mol Ther. 2012. PMID: 22491213 Free PMC article.
Maintenance of human embryonic stem cells in media conditioned by human mesenchymal stem cells obviates the requirement of exogenous basic fibroblast growth factor supplementation.
Sánchez L, Gutierrez-Aranda I, Ligero G, Martín M, Ayllón V, Real PJ, Ramos-Mejía V, Bueno C, Menendez P. Sánchez L, et al. Among authors: gutierrez aranda i. Tissue Eng Part C Methods. 2012 May;18(5):387-96. doi: 10.1089/ten.TEC.2011.0546. Epub 2012 Jan 26. Tissue Eng Part C Methods. 2012. PMID: 22136131
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