Dzamko N - Search Results

1

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Deng X, et al. Among authors: dzamko n. Nat Chem Biol. 2011 Apr;7(4):203-5. doi: 10.1038/nchembio.538. Epub 2011 Mar 6. Nat Chem Biol. 2011. PMID: 21378983 Free PMC article.

2

Editorial: Updates on inflammation in Parkinson's disease.

Dzamko N, Romero-Ramos M, Thaler A. Dzamko N, et al. Front Neurol. 2023 Jan 20;14:1138543. doi: 10.3389/fneur.2023.1138543. eCollection 2023. Front Neurol. 2023. PMID: 36741283 Free PMC article. No abstract available.

3

Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain.

Fu Y, He Y, Phan K, Bhatia S, Pickford R, Wu P, Dzamko N, Halliday GM, Kim WS. Fu Y, et al. Among authors: dzamko n. Acta Neuropathol Commun. 2022 Nov 14;10(1):165. doi: 10.1186/s40478-022-01469-7. Acta Neuropathol Commun. 2022. PMID: 36376990 Free PMC article.

4

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Nichols RJ, et al. Among authors: dzamko n. Biochem J. 2009 Oct 23;424(1):47-60. doi: 10.1042/BJ20091035. Biochem J. 2009. PMID: 19740074 Free PMC article.

5

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR. Nichols RJ, et al. Among authors: dzamko n. Biochem J. 2010 Sep 15;430(3):393-404. doi: 10.1042/BJ20100483. Biochem J. 2010. PMID: 20642453 Free PMC article.

6

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.

Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. Dzamko N, et al. Biochem J. 2010 Sep 15;430(3):405-13. doi: 10.1042/BJ20100784. Biochem J. 2010. PMID: 20659021 Free PMC article.

7

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.

Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. Dzamko N, et al. PLoS One. 2012;7(6):e39132. doi: 10.1371/journal.pone.0039132. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723946 Free PMC article.

8

Measurement of LRRK2 and Ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic Parkinson's disease patients.

Dzamko N, Chua G, Ranola M, Rowe DB, Halliday GM. Dzamko N, et al. J Parkinsons Dis. 2013;3(2):145-52. doi: 10.3233/JPD-130174. J Parkinsons Dis. 2013. PMID: 23938344

9

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, Gray NS. Deng X, et al. Among authors: dzamko n. Eur J Med Chem. 2013;70:758-67. doi: 10.1016/j.ejmech.2013.10.052. Epub 2013 Oct 29. Eur J Med Chem. 2013. PMID: 24239623 Free PMC article.

10

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N. Zhao Y, et al. Among authors: dzamko n. Neurobiol Dis. 2018 Dec;120:76-87. doi: 10.1016/j.nbd.2018.09.003. Epub 2018 Sep 5. Neurobiol Dis. 2018. PMID: 30194047 Free PMC article.

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