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A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.
Cuez T, Korkmaz B, Buharalioglu CK, Sahan-Firat S, Falck J, Malik KU, Tunctan B. Cuez T, et al. Among authors: korkmaz b. Basic Clin Pharmacol Toxicol. 2010 May;106(5):378-88. doi: 10.1111/j.1742-7843.2009.00501.x. Epub 2009 Dec 7. Basic Clin Pharmacol Toxicol. 2010. PMID: 20002062 Free PMC article.
Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.
Tunctan B, Korkmaz B, Cuez T, Kemal Buharalioglu C, Sahan-Firat S, Falck J, Malik KU. Tunctan B, et al. Among authors: korkmaz b. Basic Clin Pharmacol Toxicol. 2010 Nov;107(5):877-82. doi: 10.1111/j.1742-7843.2010.00589.x. Basic Clin Pharmacol Toxicol. 2010. PMID: 22545970 Free PMC article.
5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.
Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU. Tunctan B, et al. Among authors: korkmaz b. Prostaglandins Other Lipid Mediat. 2013 Apr-May;102-103:31-41. doi: 10.1016/j.prostaglandins.2013.01.005. Epub 2013 Feb 27. Prostaglandins Other Lipid Mediat. 2013. PMID: 23454652 Free PMC article.
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU. Tunctan B, et al. Among authors: korkmaz b. Nitric Oxide. 2013 Sep 1;33:18-41. doi: 10.1016/j.niox.2013.05.001. Epub 2013 May 14. Nitric Oxide. 2013. PMID: 23684565 Free PMC article.
Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.
Sari AN, Kacan M, Unsal D, Sahan Firat S, Kemal Buharalioglu C, Vezir O, Korkmaz B, Cuez T, Canacankatan N, Sucu N, Ayaz L, Tamer Gumus L, Gorur A, Tunctan B. Sari AN, et al. Among authors: korkmaz b. Eur J Pharmacol. 2014 Jan 15;723:234-45. doi: 10.1016/j.ejphar.2013.11.027. Epub 2013 Dec 1. Eur J Pharmacol. 2014. PMID: 24296316
173 results