Syka PM - Search Results

1

Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.

Hudson AR, Higuchi RI, Roach SL, Adams ME, Vassar A, Syka PM, Mais DE, Miner JN, Marschke KB, Zhi L. Hudson AR, et al. Among authors: syka pm. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1697-700. doi: 10.1016/j.bmcl.2011.01.093. Epub 2011 Jan 26. Bioorg Med Chem Lett. 2011. PMID: 21316964

2

Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.

Roach SL, Higuchi RI, Hudson AR, Adams ME, Syka PM, Mais DE, Miner JN, Marschke KB, Zhi L. Roach SL, et al. Among authors: syka pm. Bioorg Med Chem Lett. 2011 Jan 1;21(1):168-71. doi: 10.1016/j.bmcl.2010.11.047. Epub 2010 Nov 11. Bioorg Med Chem Lett. 2011. PMID: 21115247

3

Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.

Hudson AR, Higuchi RI, Roach SL, Valdez LJ, Adams ME, Vassar A, Rungta D, Syka PM, Mais DE, Marschke KB, Zhi L. Hudson AR, et al. Among authors: syka pm. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1654-7. doi: 10.1016/j.bmcl.2011.01.104. Epub 2011 Jan 27. Bioorg Med Chem Lett. 2011. PMID: 21324689

4

Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation.

Roach SL, Higuchi RI, Hudson AR, Vassar A, Grant VH, Lamer R, Hooper C, Rungta D, Syka PM, Mais DE, Marschke KB, Zhi L. Roach SL, et al. Among authors: syka pm. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1658-62. doi: 10.1016/j.bmcl.2011.01.106. Epub 2011 Jan 27. Bioorg Med Chem Lett. 2011. PMID: 21349714

5

Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.

Alper PB, Deane J, Betschart C, Buffet D, Collignon Zipfel G, Gordon P, Hampton J, Hawtin S, Ibanez M, Jiang T, Junt T, Knoepfel T, Liu B, Maginnis J, McKeever U, Michellys PY, Mutnick D, Nayak B, Niwa S, Richmond W, Rush JS, Syka P, Zhang Y, Zhu X. Alper PB, et al. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127366. doi: 10.1016/j.bmcl.2020.127366. Epub 2020 Jun 24. Bioorg Med Chem Lett. 2020. PMID: 32738975

6

Synergistic activation of the hydratase but not the ApoA1 gene by gemfibrozil and retinoids.

Mukherjee R, Jow L, Strasser J, Syka P, Rosen J, Heyman R. Mukherjee R, et al. Ann N Y Acad Sci. 1996 Dec 27;804:734-5. doi: 10.1111/j.1749-6632.1996.tb18684.x. Ann N Y Acad Sci. 1996. PMID: 8993608 No abstract available.

7

Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter.

Nagy L, Saydak M, Shipley N, Lu S, Basilion JP, Yan ZH, Syka P, Chandraratna RA, Stein JP, Heyman RA, Davies PJ. Nagy L, et al. J Biol Chem. 1996 Feb 23;271(8):4355-65. doi: 10.1074/jbc.271.8.4355. J Biol Chem. 1996. PMID: 8626785 Free article.

8

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

Lala DS, Syka PM, Lazarchik SB, Mangelsdorf DJ, Parker KL, Heyman RA. Lala DS, et al. Among authors: syka pm. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895-900. doi: 10.1073/pnas.94.10.4895. Proc Natl Acad Sci U S A. 1997. PMID: 9144161 Free PMC article.

9

Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.

Alper P, Betschart C, André C, Boulay T, Cheng D, Deane J, Faller M, Feifel R, Glatthar R, Han D, Hemmig R, Jiang T, Knoepfel T, Maginnis J, Mutnick D, Pei W, Ruzzante G, Syka P, Zhang G, Zhang Y, Zink F, Zipfel G, Hawtin S, Junt T, Michellys PY. Alper P, et al. ACS Med Chem Lett. 2023 Jul 31;14(8):1054-1062. doi: 10.1021/acsmedchemlett.3c00136. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583811 Free PMC article.

10

Vector PCR.

Runnebaum IB, Syka P, Sukumar S. Runnebaum IB, et al. Biotechniques. 1991 Oct;11(4):446-8, 450-2. Biotechniques. 1991. PMID: 1793574

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