Sansom O - Search Results

1

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.

Myant K, Sansom O. Myant K, et al. Among authors: sansom o. Cell Div. 2011 Feb 2;6(1):3. doi: 10.1186/1747-1028-6-3. Cell Div. 2011. PMID: 21288356 Free PMC article.

2

Mutant p53 drives invasion by promoting integrin recycling.

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Muller PA, et al. Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026. Cell. 2009. PMID: 20064378 Free article.

3

Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression.

Woodcock SA, Rushton HJ, Castañeda-Saucedo E, Myant K, White GR, Blyth K, Sansom OJ, Malliri A. Woodcock SA, et al. Curr Biol. 2010 Apr 13;20(7):669-75. doi: 10.1016/j.cub.2010.02.033. Epub 2010 Mar 25. Curr Biol. 2010. PMID: 20346677 Free PMC article.

4

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.

5

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cole AM, et al. Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Cancer Res. 2010. PMID: 20736363 Free PMC article.

6

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

Morton JP, Myant KB, Sansom OJ. Morton JP, et al. Cell Cycle. 2011 Jan 15;10(2):173-5. doi: 10.4161/cc.10.2.14350. Epub 2011 Jan 15. Cell Cycle. 2011. PMID: 21228625 No abstract available.

7

More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer.

Myant K, Sansom OJ. Myant K, et al. Mol Cell. 2011 Feb 18;41(4):369-70. doi: 10.1016/j.molcel.2011.01.028. Mol Cell. 2011. PMID: 21329875 Free article.

8

Wnt/Myc interactions in intestinal cancer: partners in crime.

Myant K, Sansom OJ. Myant K, et al. Exp Cell Res. 2011 Nov 15;317(19):2725-31. doi: 10.1016/j.yexcr.2011.08.001. Epub 2011 Aug 7. Exp Cell Res. 2011. PMID: 21851818 Review.

9

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H. Muñoz J, et al. EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166. EMBO J. 2012. PMID: 22692129 Free PMC article.

10

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.

Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. Cordero JB, et al. Development. 2012 Dec;139(24):4524-35. doi: 10.1242/dev.078261. Development. 2012. PMID: 23172913

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