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1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Anandan SK, Webb HK, Chen D, Wang YX, Aavula BR, Cases S, Cheng Y, Do ZN, Mehra U, Tran V, Vincelette J, Waszczuk J, White K, Wong KR, Zhang LN, Jones PD, Hammock BD, Patel DV, Whitcomb R, MacIntyre DE, Sabry J, Gless R. Anandan SK, et al. Among authors: cases s. Bioorg Med Chem Lett. 2011 Feb 1;21(3):983-8. doi: 10.1016/j.bmcl.2010.12.042. Epub 2010 Dec 13. Bioorg Med Chem Lett. 2011. PMID: 21211973 Free PMC article.
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV Jr. Streeper RS, et al. Among authors: cases s. Aging (Albany NY). 2012 Jan;4(1):13-27. doi: 10.18632/aging.100424. Aging (Albany NY). 2012. PMID: 22291164 Free PMC article.
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