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Page 1
Evolutionary divergence of the necroptosis effector MLKL.
Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Tanzer MC, et al. Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868910 Free PMC article.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE. Brouwer JM, et al. Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. Mol Cell. 2017. PMID: 29149594 Free article.
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM. Petrie EJ, et al. Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7. Nat Commun. 2018. PMID: 29930286 Free PMC article.
CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.
Bandala-Sanchez E, G Bediaga N, Goddard-Borger ED, Ngui K, Naselli G, Stone NL, Neale AM, Pearce LA, Wardak A, Czabotar P, Haselhorst T, Maggioni A, Hartley-Tassell LA, Adams TE, Harrison LC. Bandala-Sanchez E, et al. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7783-7788. doi: 10.1073/pnas.1722056115. Epub 2018 Jul 11. Proc Natl Acad Sci U S A. 2018. PMID: 29997173 Free PMC article.
Ensemble Properties of Bax Determine Its Function.
Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM. Robin AY, et al. Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16. Structure. 2018. PMID: 30122452 Free article.
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy.
Bernardini JP, Brouwer JM, Tan IK, Sandow JJ, Huang S, Stafford CA, Bankovacki A, Riffkin CD, Wardak AZ, Czabotar PE, Lazarou M, Dewson G. Bernardini JP, et al. Among authors: wardak az. EMBO J. 2019 Jan 15;38(2):e99916. doi: 10.15252/embj.201899916. Epub 2018 Dec 20. EMBO J. 2019. PMID: 30573668 Free PMC article.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT. van Delft MF, et al. Nat Chem Biol. 2019 Nov;15(11):1057-1066. doi: 10.1038/s41589-019-0365-8. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591564
BAK core dimers bind lipids and can be bridged by them.
Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE. Cowan AD, et al. Among authors: wardak az. Nat Struct Mol Biol. 2020 Nov;27(11):1024-1031. doi: 10.1038/s41594-020-0494-5. Epub 2020 Sep 14. Nat Struct Mol Biol. 2020. PMID: 32929280
21 results