Pérez-Galán P - Search Results

1

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.

Roué G, Pérez-Galán P, Mozos A, López-Guerra M, Xargay-Torrent S, Rosich L, Saborit-Villarroya I, Normant E, Campo E, Colomer D. Roué G, et al. Blood. 2011 Jan 27;117(4):1270-9. doi: 10.1182/blood-2010-04-278853. Epub 2010 Nov 24. Blood. 2011. PMID: 21106982 Free article.

2

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status.

Pérez-Galán P, Roué G, Villamor N, Montserrat E, Campo E, Colomer D. Pérez-Galán P, et al. Blood. 2006 Jan 1;107(1):257-64. doi: 10.1182/blood-2005-05-2091. Epub 2005 Sep 15. Blood. 2006. PMID: 16166592 Free article.

3

Mantle cell lymphoma: from pathology and molecular pathogenesis to new therapeutic perspectives.

Salaverria I, Perez-Galan P, Colomer D, Campo E. Salaverria I, et al. Haematologica. 2006 Jan;91(1):11-6. Haematologica. 2006. PMID: 16434365 No abstract available.

4

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.

Pérez-Galán P, Roué G, Villamor N, Campo E, Colomer D. Pérez-Galán P, et al. Blood. 2007 May 15;109(10):4441-9. doi: 10.1182/blood-2006-07-034173. Epub 2007 Jan 16. Blood. 2007. PMID: 17227835 Free article.

5

Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level.

Roué G, Pérez-Galán P, López-Guerra M, Villamor N, Campo E, Colomer D. Roué G, et al. J Immunol. 2007 Feb 1;178(3):1923-30. doi: 10.4049/jimmunol.178.3.1923. J Immunol. 2007. PMID: 17237443

6

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

Pérez-Galán P, Roué G, López-Guerra M, Nguyen M, Villamor N, Montserrat E, Shore GC, Campo E, Colomer D. Pérez-Galán P, et al. Leukemia. 2008 Sep;22(9):1712-20. doi: 10.1038/leu.2008.175. Epub 2008 Jul 3. Leukemia. 2008. PMID: 18596739

7

Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling.

Roué G, López-Guerra M, Milpied P, Pérez-Galán P, Villamor N, Montserrat E, Campo E, Colomer D. Roué G, et al. Clin Cancer Res. 2008 Nov 1;14(21):6907-15. doi: 10.1158/1078-0432.CCR-08-0388. Clin Cancer Res. 2008. PMID: 18980985

8

p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541.

López-Guerra M, Roué G, Pérez-Galán P, Alonso R, Villamor N, Montserrat E, Campo E, Colomer D. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76. doi: 10.1158/1078-0432.CCR-08-2382. Epub 2009 Apr 7. Clin Cancer Res. 2009. PMID: 19351760

9

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era.

Pérez-Galán P, Dreyling M, Wiestner A. Pérez-Galán P, et al. Blood. 2011 Jan 6;117(1):26-38. doi: 10.1182/blood-2010-04-189977. Epub 2010 Oct 12. Blood. 2011. PMID: 20940415 Free PMC article. Review.

10

Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation.

Pérez-Galán P, Mora-Jensen H, Weniger MA, Shaffer AL 3rd, Rizzatti EG, Chapman CM, Mo CC, Stennett LS, Rader C, Liu P, Raghavachari N, Stetler-Stevenson M, Yuan C, Pittaluga S, Maric I, Dunleavy KM, Wilson WH, Staudt LM, Wiestner A. Pérez-Galán P, et al. Blood. 2011 Jan 13;117(2):542-52. doi: 10.1182/blood-2010-02-269514. Epub 2010 Oct 18. Blood. 2011. PMID: 20956803 Free PMC article. Clinical Trial.

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