Sygowski LA - Search Results

1

4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.

Xiong H, Brugel TA, Balestra M, Brown DG, Brush KA, Hightower C, Hinkley L, Hoesch V, Kang J, Koether GM, McCauley JP Jr, McLaren FM, Panko LM, Simpson TR, Smith RW, Woods JM, Brockel B, Chhajlani V, Gadient RA, Spear N, Sygowski LA, Zhang M, Arora J, Breysse N, Wilson JM, Isaac M, Slassi A, King MM. Xiong H, et al. Among authors: sygowski la. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7381-4. doi: 10.1016/j.bmcl.2010.10.036. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 21067920

2

Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.

Brugel TA, Smith RW, Balestra M, Becker C, Daniels T, Hoerter TN, Koether GM, Throner SR, Panko LM, Folmer JJ, Cacciola J, Hunter AM, Liu R, Edwards PD, Brown DG, Gordon J, Ledonne NC, Pietras M, Schroeder P, Sygowski LA, Hirata LT, Zacco A, Peters MF. Brugel TA, et al. Among authors: sygowski la. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5847-52. doi: 10.1016/j.bmcl.2010.07.113. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20727752

3

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Varnes JG, Marcus AP, Mauger RC, Throner SR, Hoesch V, King MM, Wang X, Sygowski LA, Spear N, Gadient R, Brown DG, Campbell JB. Varnes JG, et al. Among authors: sygowski la. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1402-6. doi: 10.1016/j.bmcl.2011.01.027. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21295468

4

Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.

Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V. Zysk JR, et al. Among authors: sygowski la. Synapse. 2011 Jan;65(1):64-8. doi: 10.1002/syn.20817. Synapse. 2011. PMID: 20506301

5

Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity.

Peters MF, Zacco A, Gordon J, Maciag CM, Litwin LC, Thompson C, Schroeder P, Sygowski LA, Piser TM, Brugel TA. Peters MF, et al. Among authors: sygowski la. Eur J Pharmacol. 2011 Jul 1;661(1-3):27-34. doi: 10.1016/j.ejphar.2011.04.017. Epub 2011 Apr 27. Eur J Pharmacol. 2011. PMID: 21539838

6

Potent reversible inhibitors of the protein tyrosine phosphatase CD45.

Urbanek RA, Suchard SJ, Steelman GB, Knappenberger KS, Sygowski LA, Veale CA, Chapdelaine MJ. Urbanek RA, et al. Among authors: sygowski la. J Med Chem. 2001 May 24;44(11):1777-93. doi: 10.1021/jm000447i. J Med Chem. 2001. PMID: 11356112

7

Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs.

Peters MF, Knappenberger KS, Wilkins D, Sygowski LA, Lazor LA, Liu J, Scott CW. Peters MF, et al. Among authors: sygowski la. J Biomol Screen. 2007 Apr;12(3):312-9. doi: 10.1177/1087057106298637. Epub 2007 Feb 16. J Biomol Screen. 2007. PMID: 17307886

8

Phosphorylation of tau protein in tau-transfected 3T3 cells.

Sygowski LA, Fieles AW, Lo MM, Scott CW, Caputo CB. Sygowski LA, et al. Brain Res Mol Brain Res. 1993 Nov;20(3):221-8. doi: 10.1016/0169-328x(93)90044-p. Brain Res Mol Brain Res. 1993. PMID: 8302160

9

Properties of several protein kinases that copurify with rat spinal cord neurofilaments.

Caputo CB, Sygowski LA, Brunner WF, Scott CW, Salama AI. Caputo CB, et al. Among authors: sygowski la. Biochim Biophys Acta. 1989 Aug 15;1012(3):299-307. doi: 10.1016/0167-4889(89)90112-2. Biochim Biophys Acta. 1989. PMID: 2758040

10

Therapeutic approaches targeted at the amyloid proteins in Alzheimer's disease.

Caputo CB, Scott CW, Sobel IR, Sygowski LA, Wischik CM, Brunner WF. Caputo CB, et al. Among authors: sygowski la. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:414A-415A. doi: 10.1097/00002826-199201001-00216. Clin Neuropharmacol. 1992. PMID: 1498896 No abstract available.

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