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Page 1
4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
Xiong H, Brugel TA, Balestra M, Brown DG, Brush KA, Hightower C, Hinkley L, Hoesch V, Kang J, Koether GM, McCauley JP Jr, McLaren FM, Panko LM, Simpson TR, Smith RW, Woods JM, Brockel B, Chhajlani V, Gadient RA, Spear N, Sygowski LA, Zhang M, Arora J, Breysse N, Wilson JM, Isaac M, Slassi A, King MM. Xiong H, et al. Among authors: slassi a. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7381-4. doi: 10.1016/j.bmcl.2010.10.036. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 21067920
Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development.
Raboisson P, Breitholtz-Emanuelsson A, Dahllöf H, Edwards L, Heaton WL, Isaac M, Jarvie K, Kers A, Minidis AB, Nordmark A, Sheehan SM, Slassi A, Ström P, Terelius Y, Wensbo D, Wilson JM, Xin T, McLeod DA. Raboisson P, et al. Among authors: slassi a. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6974-9. doi: 10.1016/j.bmcl.2012.08.100. Epub 2012 Sep 21. Bioorg Med Chem Lett. 2012. PMID: 23046966
Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity.
Isaac M, Slassi A, O'Brien A, Edwards L, MacLean N, Bueschkens D, Lee DK, McCallum K, De Lannoy I, Demchyshyn L, Kamboj R. Isaac M, et al. Among authors: slassi a. Bioorg Med Chem Lett. 2000 May 1;10(9):919-21. doi: 10.1016/s0960-894x(00)00141-4. Bioorg Med Chem Lett. 2000. PMID: 10853660
25 results