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Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM. Welsh GI, et al. Among authors: mcardle ca. Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015. Cell Metab. 2010. PMID: 20889126 Free PMC article.
A role for NPY-NPY2R signaling in albuminuric kidney disease.
Lay AC, Barrington AF, Hurcombe JA, Ramnath RD, Graham M, Lewis PA, Wilson MC, Heesom KJ, Butler MJ, Perrett RM, Neal CR, Herbert E, Mountjoy E, Atan D, Nair V, Ju W, Nelson RG, Kretzler M, Satchell SC, McArdle CA, Welsh GI, Coward RJM. Lay AC, et al. Among authors: mcardle ca. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15862-15873. doi: 10.1073/pnas.2004651117. Epub 2020 Jun 19. Proc Natl Acad Sci U S A. 2020. PMID: 32561647 Free PMC article.
An information theoretic approach to insulin sensing by human kidney podocytes.
Pope RJ, Garner KL, Voliotis M, Lay AC, Betin VM, Tsaneva-Atanasova K, Welsh GI, Coward RJ, McArdle CA. Pope RJ, et al. Among authors: mcardle ca. Mol Cell Endocrinol. 2020 Dec 1;518:110976. doi: 10.1016/j.mce.2020.110976. Epub 2020 Aug 1. Mol Cell Endocrinol. 2020. PMID: 32750396
IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes.
Lay AC, Hale LJ, Stowell-Connolly H, Pope RJP, Nair V, Ju W, Marquez E, Rollason R, Hurcombe JA, Hayes B, Roberts T, Gillam L, Allington J, Nelson RG, Kretzler M, Holly JMP, Perks CM, McArdle CA, Welsh GI, Coward RJM. Lay AC, et al. Among authors: mcardle ca. Diabetologia. 2021 Jul;64(7):1690-1702. doi: 10.1007/s00125-021-05427-1. Epub 2021 Mar 24. Diabetologia. 2021. PMID: 33758952 Free PMC article.
139 results