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Page 1
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira SM, García-Echeverría C, Briggs KJ, Watkins DN, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M. Buonamici S, et al. Among authors: briggs kj. Sci Transl Med. 2010 Sep 29;2(51):51ra70. doi: 10.1126/scitranslmed.3001599. Sci Transl Med. 2010. PMID: 20881279 Free PMC article.
Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.
Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB. Ohm JE, et al. Among authors: briggs kj. Cancer Res. 2010 Oct 1;70(19):7662-73. doi: 10.1158/0008-5472.CAN-10-1361. Epub 2010 Sep 14. Cancer Res. 2010. PMID: 20841480 Free PMC article.
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.
Cottrell KM, Briggs KJ, Whittington DA, Jahic H, Ali JA, Davis CB, Gong S, Gotur D, Gu L, McCarren P, Tonini MR, Tsai A, Wilker EW, Yuan H, Zhang M, Zhang W, Huang A, Maxwell JP. Cottrell KM, et al. Among authors: briggs kj. J Med Chem. 2024 Apr 25;67(8):6064-6080. doi: 10.1021/acs.jmedchem.4c00133. Epub 2024 Apr 10. J Med Chem. 2024. PMID: 38595098 Free PMC article.
Targeting oncoproteins with a positive selection assay for protein degraders.
Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr. Koduri V, et al. Among authors: briggs kj. Sci Adv. 2021 Feb 5;7(6):eabd6263. doi: 10.1126/sciadv.abd6263. Print 2021 Feb. Sci Adv. 2021. PMID: 33547076 Free PMC article.
Peptidic degron for IMiD-induced degradation of heterologous proteins.
Koduri V, McBrayer SK, Liberzon E, Wang AC, Briggs KJ, Cho H, Kaelin WG Jr. Koduri V, et al. Among authors: briggs kj. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2539-2544. doi: 10.1073/pnas.1818109116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683719 Free PMC article.
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.
Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG Jr, Livingston DM. Li AG, et al. Among authors: briggs kj. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9600-E9609. doi: 10.1073/pnas.1807112115. Epub 2018 Sep 25. Proc Natl Acad Sci U S A. 2018. PMID: 30254159 Free PMC article.
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