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Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results.
Hayes DF, Skaar TC, Rae JM, Henry NL, Nguyen AT, Stearns V, Li L, Philips S, Desta Z, Flockhart DA; Consortium on Breast Cancer Pharmacogenomics (COBRA). Hayes DF, et al. Among authors: flockhart da. Clin Pharmacol Ther. 2010 Nov;88(5):626-9. doi: 10.1038/clpt.2010.143. Epub 2010 Sep 8. Clin Pharmacol Ther. 2010. PMID: 20827267 Free PMC article. Clinical Trial.
Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen.
Ntukidem NI, Nguyen AT, Stearns V, Rehman M, Schott A, Skaar T, Jin Y, Blanche P, Li L, Lemler S, Hayden J, Krauss RM, Desta Z, Flockhart DA, Hayes DF; Consortium on Breast Cancer Pharmacogenomics. Ntukidem NI, et al. Among authors: flockhart da. Clin Pharmacol Ther. 2008 May;83(5):702-10. doi: 10.1038/sj.clpt.6100343. Epub 2007 Aug 22. Clin Pharmacol Ther. 2008. PMID: 17713466 Free PMC article. Clinical Trial.
Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients.
Rae JM, Sikora MJ, Henry NL, Li L, Kim S, Oesterreich S, Skaar TC, Nguyen AT, Desta Z, Storniolo AM, Flockhart DA, Hayes DF, Stearns V; COBRA investigators. Rae JM, et al. Among authors: flockhart da. Pharmacogenomics J. 2009 Aug;9(4):258-64. doi: 10.1038/tpj.2009.14. Epub 2009 May 5. Pharmacogenomics J. 2009. PMID: 19421167 Free PMC article. Clinical Trial.
Clinically available pharmacogenomics tests.
Flockhart DA, Skaar T, Berlin DS, Klein TE, Nguyen AT. Flockhart DA, et al. Clin Pharmacol Ther. 2009 Jul;86(1):109-13. doi: 10.1038/clpt.2009.39. Epub 2009 Apr 15. Clin Pharmacol Ther. 2009. PMID: 19369936 Free PMC article. Review.
Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Desta Z, Kreutz Y, Nguyen AT, Li L, Skaar T, Kamdem LK, Henry NL, Hayes DF, Storniolo AM, Stearns V, Hoffmann E, Tyndale RF, Flockhart DA. Desta Z, et al. Among authors: flockhart da. Clin Pharmacol Ther. 2011 Nov;90(5):693-700. doi: 10.1038/clpt.2011.174. Epub 2011 Oct 5. Clin Pharmacol Ther. 2011. PMID: 21975350 Free PMC article. Clinical Trial.
A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone.
Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. Hartmaier RJ, et al. Among authors: flockhart da. Mol Endocrinol. 2012 Feb;26(2):220-7. doi: 10.1210/me.2011-1032. Epub 2011 Dec 15. Mol Endocrinol. 2012. PMID: 22174377 Free PMC article.
249 results