Farooqi IS - Search Results

1

Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity.

René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ, Bouvier M. René P, et al. Among authors: farooqi is. J Pharmacol Exp Ther. 2010 Dec;335(3):520-32. doi: 10.1124/jpet.110.172098. Epub 2010 Sep 8. J Pharmacol Exp Ther. 2010. PMID: 20826565

2

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS. Tan K, et al. Among authors: farooqi is. Endocrinology. 2009 Jan;150(1):114-25. doi: 10.1210/en.2008-0721. Epub 2008 Sep 18. Endocrinology. 2009. PMID: 18801902 Free PMC article.

3

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.

Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Brouwers B, et al. Among authors: farooqi is. Cell Rep. 2021 Mar 23;34(12):108862. doi: 10.1016/j.celrep.2021.108862. Cell Rep. 2021. PMID: 33761344 Free PMC article.

4

Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.

Gibson WT, Ebersole BJ, Bhattacharyya S, Clayton P, Farooqi IS, Sealfon SC, O'Rahilly S. Gibson WT, et al. Among authors: farooqi is. Can J Physiol Pharmacol. 2004 Jun;82(6):426-9. doi: 10.1139/y04-025. Can J Physiol Pharmacol. 2004. PMID: 15381968

5

Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.

Gray J, Yeo G, Hung C, Keogh J, Clayton P, Banerjee K, McAulay A, O'Rahilly S, Farooqi IS. Gray J, et al. Among authors: farooqi is. Int J Obes (Lond). 2007 Feb;31(2):359-64. doi: 10.1038/sj.ijo.0803390. Epub 2006 May 16. Int J Obes (Lond). 2007. PMID: 16702999

6

Melanocortin receptors as targets in the treatment of obesity.

Lam DD, Farooqi IS, Heisler LK. Lam DD, et al. Among authors: farooqi is. Curr Top Med Chem. 2007;7(11):1085-1097. Curr Top Med Chem. 2007. PMID: 17584129

7

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

Farooqi IS, Volders K, Stanhope R, Heuschkel R, White A, Lank E, Keogh J, O'Rahilly S, Creemers JW. Farooqi IS, et al. J Clin Endocrinol Metab. 2007 Sep;92(9):3369-73. doi: 10.1210/jc.2007-0687. Epub 2007 Jun 26. J Clin Endocrinol Metab. 2007. PMID: 17595246

8

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.

Collet TH, Dubern B, Mokrosinski J, Connors H, Keogh JM, Mendes de Oliveira E, Henning E, Poitou-Bernert C, Oppert JM, Tounian P, Marchelli F, Alili R, Le Beyec J, Pépin D, Lacorte JM, Gottesdiener A, Bounds R, Sharma S, Folster C, Henderson B, O'Rahilly S, Stoner E, Gottesdiener K, Panaro BL, Cone RD, Clément K, Farooqi IS, Van der Ploeg LHT. Collet TH, et al. Among authors: farooqi is. Mol Metab. 2017 Oct;6(10):1321-1329. doi: 10.1016/j.molmet.2017.06.015. Epub 2017 Jul 8. Mol Metab. 2017. PMID: 29031731 Free PMC article. Clinical Trial.

9

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S. Farooqi IS, et al. J Clin Invest. 2000 Jul;106(2):271-9. doi: 10.1172/JCI9397. J Clin Invest. 2000. PMID: 10903343 Free PMC article.

10

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S. Yeo GS, et al. Among authors: farooqi is. Hum Mol Genet. 2003 Mar 1;12(5):561-74. doi: 10.1093/hmg/ddg057. Hum Mol Genet. 2003. PMID: 12588803

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