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Page 1
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.
Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, Brinker A, Engels IH, Taylor J, Chatterjee AK, Fantauzzi P, Glynne RJ, Van Voorhis WC, Kuhen KL. Crowther GJ, et al. Among authors: engels ih. Mol Biochem Parasitol. 2011 Jan;175(1):21-9. doi: 10.1016/j.molbiopara.2010.08.005. Epub 2010 Sep 15. Mol Biochem Parasitol. 2011. PMID: 20813141 Free PMC article.
Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.
Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC. Ramadoss NS, et al. Among authors: engels ih. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3. Proc Natl Acad Sci U S A. 2013. PMID: 23733947 Free PMC article.
A biochemical screen for GroEL/GroES inhibitors.
Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E. Johnson SM, et al. Among authors: engels ih. Bioorg Med Chem Lett. 2014 Feb 1;24(3):786-9. doi: 10.1016/j.bmcl.2013.12.100. Epub 2014 Jan 2. Bioorg Med Chem Lett. 2014. PMID: 24418775
Chemical activation of the mechanotransduction channel Piezo1.
Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Syeda R, et al. Among authors: engels ih. Elife. 2015 May 22;4:e07369. doi: 10.7554/eLife.07369. Elife. 2015. PMID: 26001275 Free PMC article.
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M. Buddenkotte J, et al. Among authors: engels ih. J Invest Dermatol. 2005 Jan;124(1):38-45. doi: 10.1111/j.0022-202X.2004.23539.x. J Invest Dermatol. 2005. PMID: 15654951 Free article.
26 results