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Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.
Shetty GK, Matarese G, Magkos F, Moon HS, Liu X, Brennan AM, Mylvaganam G, Sykoutri D, Depaoli AM, Mantzoros CS. Shetty GK, et al. Among authors: depaoli am. Eur J Endocrinol. 2011 Aug;165(2):249-54. doi: 10.1530/EJE-11-0252. Epub 2011 May 20. Eur J Endocrinol. 2011. PMID: 21602313 Free PMC article. Clinical Trial.
Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.
Chan JL, Bullen J, Stoyneva V, Depaoli AM, Addy C, Mantzoros CS. Chan JL, et al. Among authors: depaoli am. J Clin Endocrinol Metab. 2005 Mar;90(3):1618-24. doi: 10.1210/jc.2004-1921. Epub 2004 Dec 21. J Clin Endocrinol Metab. 2005. PMID: 15613407 Clinical Trial.
74 results