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Page 1
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Melrose HL, Dächsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM, Kent CB, Korvatska E, Taylor JP, Witten L, Liang YQ, Beevers JE, Boules M, Dugger BN, Serna VA, Gaukhman A, Yu X, Castanedes-Casey M, Braithwaite AT, Ogholikhan S, Yu N, Bass D, Tyndall G, Schellenberg GD, Dickson DW, Janus C, Farrer MJ. Melrose HL, et al. Among authors: hinkle km. Neurobiol Dis. 2010 Dec;40(3):503-17. doi: 10.1016/j.nbd.2010.07.010. Epub 2010 Jul 24. Neurobiol Dis. 2010. PMID: 20659558 Free PMC article.
Identification of potential protein interactors of Lrrk2.
Dächsel JC, Taylor JP, Mok SS, Ross OA, Hinkle KM, Bailey RM, Hines JH, Szutu J, Madden B, Petrucelli L, Farrer MJ. Dächsel JC, et al. Among authors: hinkle km. Parkinsonism Relat Disord. 2007 Oct;13(7):382-5. doi: 10.1016/j.parkreldis.2007.01.008. Epub 2007 Apr 2. Parkinsonism Relat Disord. 2007. PMID: 17400507 Free PMC article.
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ. Melrose HL, et al. Among authors: hinkle km. Neuroscience. 2007 Jul 29;147(4):1047-58. doi: 10.1016/j.neuroscience.2007.05.027. Epub 2007 Jul 3. Neuroscience. 2007. PMID: 17611037
In vivo silencing of alpha-synuclein using naked siRNA.
Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer MJ. Lewis J, et al. Mol Neurodegener. 2008 Nov 1;3:19. doi: 10.1186/1750-1326-3-19. Mol Neurodegener. 2008. PMID: 18976489 Free PMC article.
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.
Dachsel JC, Nishioka K, Vilariño-Güell C, Lincoln SJ, Soto-Ortolaza AI, Kachergus J, Hinkle KM, Heckman MG, Jasinska-Myga B, Taylor JP, Dickson DW, Gibson RA, Hentati F, Ross OA, Farrer MJ. Dachsel JC, et al. Among authors: hinkle km. Mech Ageing Dev. 2010 Mar;131(3):210-4. doi: 10.1016/j.mad.2010.01.009. Epub 2010 Feb 6. Mech Ageing Dev. 2010. PMID: 20144646 Free PMC article.
Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice.
Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH. Winner B, et al. Among authors: hinkle km. Neurobiol Dis. 2011 Mar;41(3):706-16. doi: 10.1016/j.nbd.2010.12.008. Epub 2010 Dec 16. Neurobiol Dis. 2011. PMID: 21168496 Free PMC article.
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