Young DW - Search Results

1

Distinct biological network properties between the targets of natural products and disease genes.

Dancík V, Seiler KP, Young DW, Schreiber SL, Clemons PA. Dancík V, et al. Among authors: young dw. J Am Chem Soc. 2010 Jul 14;132(27):9259-61. doi: 10.1021/ja102798t. J Am Chem Soc. 2010. PMID: 20565092 Free PMC article.

2

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD 4th, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA. Marcaurelle LA, et al. Among authors: young dw. J Am Chem Soc. 2010 Dec 1;132(47):16962-76. doi: 10.1021/ja105119r. Epub 2010 Nov 10. J Am Chem Soc. 2010. PMID: 21067169 Free PMC article.

3

Route to three-dimensional fragments using diversity-oriented synthesis.

Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, Young DW. Hung AW, et al. Among authors: young dw. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6799-804. doi: 10.1073/pnas.1015271108. Epub 2011 Apr 11. Proc Natl Acad Sci U S A. 2011. PMID: 21482811 Free PMC article.

4

Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.

Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, Young DW. Wang Y, et al. Among authors: young dw. J Am Chem Soc. 2011 Jun 22;133(24):9196-9. doi: 10.1021/ja202012s. Epub 2011 May 27. J Am Chem Soc. 2011. PMID: 21557625 Free PMC article.

5

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.

Zhong C, Wang Y, Hung AW, Schreiber SL, Young DW. Zhong C, et al. Among authors: young dw. Org Lett. 2011 Oct 21;13(20):5556-9. doi: 10.1021/ol202276h. Epub 2011 Sep 14. Org Lett. 2011. PMID: 21916463

6

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK. Yuan Y, et al. Among authors: young dw. Chem Biol. 2013 Dec 19;20(12):1513-22. doi: 10.1016/j.chembiol.2013.10.013. Epub 2013 Nov 27. Chem Biol. 2013. PMID: 24290880 Free PMC article.

7

Synthetic chemistry: An upfront investment.

Young DW. Young DW. Nat Chem Biol. 2010 Mar;6(3):174-175. doi: 10.1038/nchembio.325. Nat Chem Biol. 2010. PMID: 20154664 No abstract available.

8

Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes.

Wang Y, Jimenez M, Sheehan P, Zhong C, Hung AW, Tam CP, Young DW. Wang Y, et al. Among authors: young dw. Org Lett. 2013 Mar 15;15(6):1218-21. doi: 10.1021/ol400134d. Epub 2013 Feb 28. Org Lett. 2013. PMID: 23448432

9

Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.

Kelly AR, Wei J, Kesavan S, Marié JC, Windmon N, Young DW, Marcaurelle LA. Kelly AR, et al. Among authors: young dw. Org Lett. 2009 Jun 4;11(11):2257-60. doi: 10.1021/ol900562u. Org Lett. 2009. PMID: 19473044 Free PMC article.

10

Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.

Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, Marcaurelle LA. Pandya BA, et al. Among authors: young dw. Tetrahedron. 2011 Aug 26;67(34):6131-6137. doi: 10.1016/j.tet.2011.06.043. Tetrahedron. 2011. PMID: 21822337 Free PMC article.

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