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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J. Marcheva B, et al. Among authors: omura c. Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253. Nature. 2010. PMID: 20562852 Free PMC article.
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Glawe B, Cantrell DR, Inayat S, Olvera MA, Vessey KA, McCall MA, Maddox D, Morgans CW, Young B, Pletcher MT, Mullins RF, Troy JB, Takahashi JS. Pinto LH, et al. Among authors: omura c. Vis Neurosci. 2007 Jan-Feb;24(1):111-23. doi: 10.1017/S0952523807070149. Vis Neurosci. 2007. PMID: 17430614 Free PMC article.
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Shimomura K, Lowrey PL, Vitaterna MH, Buhr ED, Kumar V, Hanna P, Omura C, Izumo M, Low SS, Barrett RK, LaRue SI, Green CB, Takahashi JS. Shimomura K, et al. Among authors: omura c. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8399-403. doi: 10.1073/pnas.1004368107. Epub 2010 Apr 19. Proc Natl Acad Sci U S A. 2010. PMID: 20404168 Free PMC article.
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS. Shimomura K, et al. Among authors: omura c. Elife. 2013 Apr 9;2:e00426. doi: 10.7554/eLife.00426. Elife. 2013. PMID: 23580255 Free PMC article.
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J. Peek CB, et al. Among authors: omura c. Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19. Science. 2013. PMID: 24051248 Free PMC article.
Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.
Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J. Cedernaes J, et al. Among authors: omura c. Cell Metab. 2019 May 7;29(5):1078-1091.e5. doi: 10.1016/j.cmet.2019.01.023. Epub 2019 Feb 28. Cell Metab. 2019. PMID: 30827863 Free PMC article.
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