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The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.
Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. Okawa T, et al. Among authors: rustgi ak. Genes Dev. 2007 Nov 1;21(21):2788-803. doi: 10.1101/gad.1544507. Genes Dev. 2007. PMID: 17974918 Free PMC article.
Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.
Ohashi S, Natsuizaka M, Wong GS, Michaylira CZ, Grugan KD, Stairs DB, Kalabis J, Vega ME, Kalman RA, Nakagawa M, Klein-Szanto AJ, Herlyn M, Diehl JA, Rustgi AK, Nakagawa H. Ohashi S, et al. Among authors: rustgi ak. Cancer Res. 2010 May 15;70(10):4174-84. doi: 10.1158/0008-5472.CAN-09-4614. Epub 2010 Apr 27. Cancer Res. 2010. PMID: 20424117 Free PMC article.
Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer.
Michaylira CZ, Wong GS, Miller CG, Gutierrez CM, Nakagawa H, Hammond R, Klein-Szanto AJ, Lee JS, Kim SB, Herlyn M, Diehl JA, Gimotty P, Rustgi AK. Michaylira CZ, et al. Among authors: rustgi ak. Cancer Res. 2010 Jul 1;70(13):5281-92. doi: 10.1158/0008-5472.CAN-10-0704. Epub 2010 Jun 1. Cancer Res. 2010. PMID: 20516120 Free PMC article.
405 results