Chang L - Search Results

1

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Wisén S, et al. Among authors: chang l. ACS Chem Biol. 2010 Jun 18;5(6):611-22. doi: 10.1021/cb1000422. ACS Chem Biol. 2010. PMID: 20481474 Free PMC article.

2

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK.

Chang L, Bertelsen EB, Wisén S, Larsen EM, Zuiderweg ER, Gestwicki JE. Chang L, et al. Anal Biochem. 2008 Jan 15;372(2):167-76. doi: 10.1016/j.ab.2007.08.020. Epub 2007 Aug 22. Anal Biochem. 2008. PMID: 17904512

3

Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase.

Wisén S, Androsavich J, Evans CG, Chang L, Gestwicki JE. Wisén S, et al. Among authors: chang l. Bioorg Med Chem Lett. 2008 Jan 1;18(1):60-5. doi: 10.1016/j.bmcl.2007.11.027. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18060774

4

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.

Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER. Bertelsen EB, et al. Among authors: chang l. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8471-6. doi: 10.1073/pnas.0903503106. Epub 2009 May 13. Proc Natl Acad Sci U S A. 2009. PMID: 19439666 Free PMC article.

5

Heat shock protein 70 (hsp70) as an emerging drug target.

Evans CG, Chang L, Gestwicki JE. Evans CG, et al. Among authors: chang l. J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f. J Med Chem. 2010. PMID: 20334364 Free PMC article. Review. No abstract available.

6

Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK).

Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Chang L, et al. J Biol Chem. 2010 Jul 9;285(28):21282-91. doi: 10.1074/jbc.M110.124149. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439464 Free PMC article.

7

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism.

Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE. Chang L, et al. Chem Biol. 2011 Feb 25;18(2):210-21. doi: 10.1016/j.chembiol.2010.12.010. Chem Biol. 2011. PMID: 21338918 Free PMC article.

8

Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome.

Srinivasan SR, Gillies AT, Chang L, Thompson AD, Gestwicki JE. Srinivasan SR, et al. Among authors: chang l. Mol Biosyst. 2012 Sep;8(9):2323-33. doi: 10.1039/c2mb25145k. Epub 2012 Jun 25. Mol Biosyst. 2012. PMID: 22732719 Free PMC article.

9

Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK.

Ung PM, Thompson AD, Chang L, Gestwicki JE, Carlson HA. Ung PM, et al. Among authors: chang l. PLoS Comput Biol. 2013;9(11):e1003279. doi: 10.1371/journal.pcbi.1003279. Epub 2013 Nov 21. PLoS Comput Biol. 2013. PMID: 24277995 Free PMC article.

10

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. Miyata Y, et al. Among authors: chang l. J Biomol Screen. 2010 Dec;15(10):1211-9. doi: 10.1177/1087057110380571. Epub 2010 Oct 6. J Biomol Screen. 2010. PMID: 20926844 Free PMC article.

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