Schofield C - Search Results

1

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Kawamura A, et al. Among authors: schofield c. Anal Biochem. 2010 Sep 1;404(1):86-93. doi: 10.1016/j.ab.2010.04.030. Epub 2010 May 21. Anal Biochem. 2010. PMID: 20435012 Free PMC article.

2

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. McDonough MA, et al. J Biol Chem. 2005 Dec 9;280(49):41101-10. doi: 10.1074/jbc.M507528200. Epub 2005 Sep 25. J Biol Chem. 2005. PMID: 16186124 Free article.

3

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: schofield cj. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

4

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

5

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

Mecinović J, Chowdhury R, Flashman E, Schofield CJ. Mecinović J, et al. Anal Biochem. 2009 Oct 15;393(2):215-21. doi: 10.1016/j.ab.2009.06.029. Epub 2009 Jun 27. Anal Biochem. 2009. PMID: 19563769

6

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ. Sekirnik R, et al. Chem Commun (Camb). 2009 Nov 14;(42):6376-8. doi: 10.1039/b916357c. Epub 2009 Sep 28. Chem Commun (Camb). 2009. PMID: 19841782

7

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.

Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. Loenarz C, et al. Among authors: schofield cj. Hum Mol Genet. 2010 Jan 15;19(2):217-22. doi: 10.1093/hmg/ddp480. Epub 2009 Oct 19. Hum Mol Genet. 2010. PMID: 19843542 Free PMC article.

8

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Yue WW, et al. Among authors: schofield cj. FEBS Lett. 2010 Feb 19;584(4):825-30. doi: 10.1016/j.febslet.2009.12.055. Epub 2010 Jan 12. FEBS Lett. 2010. PMID: 20067792 Free article.

9

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2010 Feb 25;53(4):1810-8. doi: 10.1021/jm901680b. J Med Chem. 2010. PMID: 20088513 Free PMC article.

10

A miniaturized screen for inhibitors of Jumonji histone demethylases.

Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. Sakurai M, et al. Mol Biosyst. 2010 Feb;6(2):357-64. doi: 10.1039/b912993f. Epub 2009 Oct 8. Mol Biosyst. 2010. PMID: 20094655 Free PMC article.

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