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Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Takuji Shirasawa TS, Mizushima N, Otsu K. Taneike M, et al. Among authors: takeda t. Autophagy. 2010 Jul;6(5):600-6. doi: 10.4161/auto.6.5.11947. Epub 2010 Jul 1. Autophagy. 2010. PMID: 20431347
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Hori M. Higuchi Y, et al. Among authors: takeda t. J Biol Chem. 2003 Jun 6;278(23):20770-7. doi: 10.1074/jbc.M213203200. Epub 2003 Apr 2. J Biol Chem. 2003. PMID: 12672819 Free article.
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Hikoso S, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, Otsu K. Yamaguchi O, et al. Among authors: takeda t. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15883-8. doi: 10.1073/pnas.2136717100. Epub 2003 Dec 9. Proc Natl Acad Sci U S A. 2003. PMID: 14665690 Free PMC article.
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
Hirotani S, Higuchi Y, Nishida K, Nakayama H, Yamaguchi O, Hikoso S, Takeda T, Kashiwase K, Watanabe T, Asahi M, Taniike M, Tsujimoto I, Matsumura Y, Sasaki T, Hori M, Otsu K. Hirotani S, et al. Among authors: takeda t. J Mol Cell Cardiol. 2004 Jun;36(6):799-807. doi: 10.1016/j.yjmcc.2004.03.002. J Mol Cell Cardiol. 2004. PMID: 15158121
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, Backx PH, Kurihara S, Hori M, MacLennan DH. Asahi M, et al. Among authors: takeda t. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204. doi: 10.1073/pnas.0402596101. Epub 2004 Jun 16. Proc Natl Acad Sci U S A. 2004. PMID: 15201433 Free PMC article.
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. Yamaguchi O, et al. Among authors: takeda t. J Clin Invest. 2004 Oct;114(7):937-43. doi: 10.1172/JCI20317. J Clin Invest. 2004. PMID: 15467832 Free PMC article.
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, Otsu K. Hikoso S, et al. Among authors: takeda t. Circulation. 2004 Oct 26;110(17):2631-7. doi: 10.1161/01.CIR.0000146798.70980.9A. Epub 2004 Oct 18. Circulation. 2004. PMID: 15492321
3,845 results