Differences in the transient kinetics of the binding of D-ADP and its mirror image L-ADP to human 3-phosphoglycerate kinase revealed by the presence of 3-phosphoglycerate.
Gondeau C, Chaloin L, Varga A, Roy B, Lallemand P, Périgaud C, Barman T, Vas M, Lionne C.
Gondeau C, et al. Among authors: varga a.
Biochemistry. 2008 Mar 18;47(11):3462-73. doi: 10.1021/bi7023145. Epub 2008 Feb 21.
Biochemistry. 2008.
PMID: 18288812
L-Nucleosides comprise a new class of antiviral and anticancer agents that are converted in vivo by a cascade of kinases to pharmacologically active nucleoside triphosphates. ...The difference is unexpected because l-ADP is almost as catalytically competent as d-ADP …
L-Nucleosides comprise a new class of antiviral and anticancer agents that are converted in vivo by a cascade of kinases to ph …