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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. Coomaraswamy J, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74. doi: 10.1073/pnas.1001056107. Epub 2010 Apr 12. Proc Natl Acad Sci U S A. 2010. PMID: 20385796 Free PMC article.
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Mahler J, et al. Neurobiol Aging. 2015 Jul;36(7):2241-2247. doi: 10.1016/j.neurobiolaging.2015.03.011. Epub 2015 Mar 25. Neurobiol Aging. 2015. PMID: 25911278 Free PMC article.
Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates.
Klingstedt T, Shirani H, Mahler J, Wegenast-Braun BM, Nyström S, Goedert M, Jucker M, Nilsson KP. Klingstedt T, et al. Among authors: wegenast braun bm. Chemistry. 2015 Jun 15;21(25):9072-82. doi: 10.1002/chem.201500556. Epub 2015 May 26. Chemistry. 2015. PMID: 26013403 Free PMC article.
Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.
Novotny R, Langer F, Mahler J, Skodras A, Vlachos A, Wegenast-Braun BM, Kaeser SA, Neher JJ, Eisele YS, Pietrowski MJ, Nilsson KP, Deller T, Staufenbiel M, Heimrich B, Jucker M. Novotny R, et al. Among authors: wegenast braun bm. J Neurosci. 2016 May 4;36(18):5084-93. doi: 10.1523/JNEUROSCI.0258-16.2016. J Neurosci. 2016. PMID: 27147660 Free PMC article.
Early Aβ reduction prevents progression of cerebral amyloid angiopathy.
Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Skodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M. Schelle J, et al. Among authors: wegenast braun bm. Ann Neurol. 2019 Oct;86(4):561-571. doi: 10.1002/ana.25562. Epub 2019 Aug 19. Ann Neurol. 2019. PMID: 31359452
21 results