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Page 1
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. Coomaraswamy J, et al. Among authors: mathews pm. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74. doi: 10.1073/pnas.1001056107. Epub 2010 Apr 12. Proc Natl Acad Sci U S A. 2010. PMID: 20385796 Free PMC article.
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.
Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M. Radde R, et al. Among authors: mathews pm. EMBO Rep. 2006 Sep;7(9):940-6. doi: 10.1038/sj.embor.7400784. Epub 2006 Aug 11. EMBO Rep. 2006. PMID: 16906128 Free PMC article.
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Meyer-Luehmann M, et al. Among authors: mathews pm. Science. 2006 Sep 22;313(5794):1781-4. doi: 10.1126/science.1131864. Science. 2006. PMID: 16990547
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M. Grathwohl SA, et al. Among authors: mathews pm. Nat Neurosci. 2009 Nov;12(11):1361-3. doi: 10.1038/nn.2432. Epub 2009 Oct 18. Nat Neurosci. 2009. PMID: 19838177 Free PMC article.
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Mahler J, et al. Among authors: mathews pm. Neurobiol Aging. 2015 Jul;36(7):2241-2247. doi: 10.1016/j.neurobiolaging.2015.03.011. Epub 2015 Mar 25. Neurobiol Aging. 2015. PMID: 25911278 Free PMC article.
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Mastrangelo P, et al. Among authors: mathews pm. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8972-7. doi: 10.1073/pnas.0500940102. Epub 2005 Jun 10. Proc Natl Acad Sci U S A. 2005. PMID: 15951428 Free PMC article.
In vivo reduction of amyloid-beta by a mutant copper transporter.
Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. Phinney AL, et al. Among authors: mathews pm. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14193-8. doi: 10.1073/pnas.2332851100. Epub 2003 Nov 14. Proc Natl Acad Sci U S A. 2003. PMID: 14617772 Free PMC article.
Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.
Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Morales-Corraliza J, et al. Among authors: mathews pm. Neurobiol Aging. 2013 Jan;34(1):137-45. doi: 10.1016/j.neurobiolaging.2012.04.007. Epub 2012 May 18. Neurobiol Aging. 2013. PMID: 22608241 Free PMC article.
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M. Herzig MC, et al. Among authors: mathews pm. Nat Neurosci. 2004 Sep;7(9):954-60. doi: 10.1038/nn1302. Epub 2004 Aug 15. Nat Neurosci. 2004. PMID: 15311281 Free article.
130 results