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The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells.
Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW. Ho KK, et al. FEBS J. 2009 Aug;276(15):4037-50. doi: 10.1111/j.1742-4658.2009.07112.x. Epub 2009 Jun 22. FEBS J. 2009. PMID: 19549188 Free article.
The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.
Di Fruscia P, Ho KK, Laohasinnarong S, Khongkow M, Kroll SH, Islam SA, Sternberg MJ, Schmidtkunz K, Jung M, Lam EW, Fuchter MJ. Di Fruscia P, et al. Among authors: ho kk. Medchemcomm. 2012 Mar 1;(3):10.1039/C2MD00290F. doi: 10.1039/C2MD00290F. Medchemcomm. 2012. PMID: 24340169 Free PMC article.
642 results